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Can quality of recovery be enhanced by premedication with midazolam?: A prospective, randomized, double-blind study in females undergoing breast surgery

 Myoung Hwa Kim  ;  Min Soo Kim  ;  Jae Hoon Lee  ;  Jae Hi Seo  ;  Jeong-Rim Lee 
 MEDICINE, Vol.96(7) : 6017, 2017 
Journal Title
Issue Date
Adult ; Aged ; Anesthetics, Intravenous/administration & dosage ; Anxiety/drug therapy* ; Breast Neoplasms/psychology ; Breast Neoplasms/surgery ; Double-Blind Method ; Emotions ; Female ; Health Status ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/therapeutic use* ; Mastectomy/methods* ; Mental Health ; Midazolam/administration & dosage ; Midazolam/therapeutic use* ; Middle Aged ; Pain, Postoperative/epidemiology ; Piperidines/administration & dosage ; Propofol/administration & dosage ; Prospective Studies ; Quality of Life ; Republic of Korea ; Young Adult
mastectomy ; midazolam ; premedication ; quality of recovery
BACKGROUND: Preoperative anxiety is known to be related with the postoperative outcomes, although it remains unclear whether pharmacologic anxiolysis preoperatively leads to better postanesthesia recovery. Hence, the purpose of this study was to assess whether midazolam premedication would result in improved Quality of Recovery-40 survey scores, as a postoperative recovery parameter, in female patients undergoing mastectomy. METHODS: This randomized double-blind study was performed at Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea. Eighty-two females undergoing breast cancer surgery with propofol-remifentanil anesthesia were enrolled and randomized to receive midazolam 0.02 mg kg (group M) or saline (group C). Anesthesia was conducted with total intravenous anesthesia using propofol and remifentanil. On postoperative day 1, the Quality of Recovery-40 survey scores were surveyed. RESULTS: The global Quality of Recovery-40 survey scores on postoperative day 1 did not significantly differ between groups M and C (183 vs 181, P = 0.568). However, the induction time was significantly shorter in group M (3.2 vs 4.5 min, P < 0.001), as was the total intraoperative propofol consumption (705 vs 1004 mg; P = 0.022). CONCLUSION: Midazolam premedication does not seem to improve the postoperative quality of recovery, though group M showed faster induction and less propofol consumption.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hwa(김명화) ORCID logo https://orcid.org/0000-0003-4723-9425
Kim, Min Soo(김민수) ORCID logo https://orcid.org/0000-0001-8760-4568
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0001-6679-2782
Lee, Jeong Rim(이정림) ORCID logo https://orcid.org/0000-0002-7425-0462
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