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Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice

DC FieldValueLanguage
dc.contributor.author이민구-
dc.date.accessioned2017-11-02T08:18:21Z-
dc.date.available2017-11-02T08:18:21Z-
dc.date.issued2017-
dc.identifier.issn0028-3908-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154316-
dc.description.abstractAutism spectrum disorders (ASDs) are a group of developmental disorders that cause variable and heterogeneous phenotypes across three behavioral domains such as atypical social behavior, disrupted communications, and highly restricted and repetitive behaviors. In addition to these core symptoms, other neurological abnormalities are associated with ASD, including intellectual disability (ID). However, the molecular etiology underlying these behavioral heterogeneities in ASD is unclear. Mutations in SHANK2 genes are associated with ASD and ID. Interestingly, two lines of Shank2 knockout mice (e6-7 KO and e7 KO) showed shared and distinct phenotypes. Here, we found that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 e6-7, but not in e7 KO mice compared with their own wild type littermates. Furthermore, treatment of Shank2 e6-7 KO mice with an allosteric modulator for the GABAA receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2 e6-7 KO mice. This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherPergamon Press-
dc.relation.isPartOfNEUROPHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAutism Spectrum Disorder/physiopathology-
dc.subject.MESHCA1 Region, Hippocampal/physiology*-
dc.subject.MESHInhibitory Postsynaptic Potentials*-
dc.subject.MESHMale-
dc.subject.MESHMaze Learning/physiology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMutation-
dc.subject.MESHNerve Tissue Proteins/genetics-
dc.subject.MESHNerve Tissue-
dc.subject.MESHProteins/metabolism*-
dc.subject.MESHNeurons/physiology-
dc.subject.MESHReceptors, GABA-A/genetics-
dc.subject.MESHReceptors, GABA-A/metabolism-
dc.subject.MESHSocial Behavior-
dc.subject.MESHSpatial Memory/physiology*-
dc.titleEnhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pharmacology-
dc.contributor.googleauthorChae-Seok Lim-
dc.contributor.googleauthorHyopil Kim-
dc.contributor.googleauthorNam-Kyung Yu-
dc.contributor.googleauthorSukjae Joshua Kang-
dc.contributor.googleauthorTaeHyun Kim-
dc.contributor.googleauthorHyoung-Gon Ko-
dc.contributor.googleauthorJaehyun Lee-
dc.contributor.googleauthorJung-eun Yang-
dc.contributor.googleauthorHyun-Hee Ryu-
dc.contributor.googleauthorTaesung Park-
dc.contributor.googleauthorJungsoo Gim-
dc.contributor.googleauthorHye Jin Nam-
dc.contributor.googleauthorSung Hee Baek-
dc.contributor.googleauthorStephanie Wegener-
dc.contributor.googleauthorDietmar Schmitz-
dc.contributor.googleauthorTobias M. Boeckers-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorEunjoon Kim-
dc.contributor.googleauthorJae-Hyung Lee-
dc.contributor.googleauthorYong-Seok Lee-
dc.contributor.googleauthorBong-Kiun Kaang-
dc.identifier.doi10.1016/j.neuropharm.2016.08.016-
dc.contributor.localIdA02781-
dc.relation.journalcodeJ02352-
dc.identifier.eissn1873-7064-
dc.identifier.pmid27544825-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0028390816303513-
dc.subject.keywordAutism spectrum disorders-
dc.subject.keywordGabra2-
dc.subject.keywordI/E ratio-
dc.subject.keywordShank2-
dc.subject.keywordSpatial memory-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.affiliatedAuthorLee, Min Goo-
dc.citation.titleNeuropharmacology-
dc.citation.volume112-
dc.citation.numberPt. A-
dc.citation.startPage104-
dc.citation.endPage112-
dc.identifier.bibliographicCitationNEUROPHARMACOLOGY, Vol.112(Pt. A) : 104-112, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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