0 160

Cited 9 times in

Synaptic functions of the IQSEC family of ADP-ribosylation factor guanine nucleotide exchange factors

Authors
 Ji Won Um 
Citation
 NEUROSCIENCE RESEARCH, Vol.116 : 54-59, 2017 
Journal Title
 NEUROSCIENCE RESEARCH 
ISSN
 0168-0102 
Issue Date
2017
MeSH
Animals ; Brain/metabolism ; Carrier Proteins/metabolism ; Guanine Nucleotide Exchange Factors/chemistry ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism* ; Humans ; Membrane Proteins/metabolism ; Mental Disorders/metabolism ; Neuronal Plasticity ; Protein Domains ; Synapses/metabolism* ; Synaptic Transmission
Keywords
ARF ; ARF-GEF ; IQSECs ; Synaptic formation ; Synaptic transmission ; XLID
Abstract
Postsynaptic scaffolding proteins interact with numerous synaptic proteins to ensure the organization and specialization of functional excitatory and inhibitory synapses. IQSECs (IQ motif and SEC7 domain-containing proteins) are a class of ADP ribosylation factor-guanine nucleotide exchange factors (ARF-GEFs), whose functions are beginning to be understood as both scaffolding and signaling proteins. Specifically, IQSEC1 binds to PSD-95, and IQSEC2 functions as a regulator of AMPA receptor trafficking at excitatory synapses, whereas IQSEC3 interacts with gephyrin to promote inhibitory synapse development. Here, I review the currently known findings on IQSECs and discuss the possible relations between dysfunctions of IQSECs and the pathophysiology of brain disorders.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168010216300906
DOI
10.1016/j.neures.2016.06.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Um, Ji Won(엄지원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154305
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse