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IBD immunopathogenesis: A comprehensive review of inflammatory molecule

Authors
 Jae Hyon Park  ;  Laurent Peyrin-Biroulet  ;  Michael Eisenhut  ;  Jae Il Shin 
Citation
 AUTOIMMUNITY REVIEWS, Vol.16(4) : 416-426, 2017 
Journal Title
 AUTOIMMUNITY REVIEWS 
ISSN
 1568-9972 
Issue Date
2017
MeSH
Anti-Inflammatory Agents/therapeutic use* ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/immunology* ; Crohn Disease/diagnosis ; Crohn Disease/immunology* ; Humans ; Inflammasomes/metabolism* ; Inflammatory Bowel Diseases/immunology* ; Inflammatory Bowel Diseases/pathology
Abstract
Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic inflammatory conditions of the gastrointestinal tract. Abnormal expressions of pro- and anti-inflammatory molecules have been described to cause an imbalance to the gut innate and adaptive immunity, and recently a large portion of research in IBD has been geared towards identifying novel molecules that may be used as potential therapeutic targets. Understanding of these inflammatory molecules has suggested that although ulcerative colitis and Crohn's disease share many common clinical symptoms and signs, they are in fact two separate clinical entities characterized by different immunopathogenesis. In this review, we comprehensively discuss the roles of numerous inflammatory molecules including but not limited to cytokines, chemokines, inflammasomes, microRNAs and neuropeptides and their expression status in ulcerative colitis and Crohn's disease in relation to their effects on the overall intestinal inflammatory process.
Full Text
http://www.sciencedirect.com/science/article/pii/S1568997217300538
DOI
10.1016/j.autrev.2017.02.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154300
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