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In vitro activity of tigecycline alone and antimicrobial combinations against clinical Neisseria gonorrhoeae isolates

Authors
 Hyukmin Lee  ;  Hyunsoo Kim  ;  Young Hee Seo  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Kyungwon Lee  ;  Younsop Chong 
Citation
 Diagnostic Microbiology and Infectious Disease, Vol.87 : 160-162, 2017 
Journal Title
 Diagnostic Microbiology and Infectious Disease 
ISSN
 0732-8893 
Issue Date
2017
MeSH
Anti-Bacterial Agents/pharmacology* ; Drug Synergism* ; Gonorrhea/microbiology ; Humans ; Microbial Sensitivity Tests ; Minocycline/analogs & derivatives* ; Minocycline/pharmacology ; Neisseria gonorrhoeae/drug effects* ; Neisseria gonorrhoeae/isolation & purification
Keywords
Combination treatment ; Gonorrhea ; In vitro activity ; Moxifloxacin ; Synergy ; Tigecycline
Abstract
In this study, we determined the in vitro activity of various combinations of antimicrobial agents against 54 Neisseria gonorrhoeae isolates. The combined activity of ceftriaxone (CRO) and azithromycin (AZM), CRO and doxycycline (DOX), CRO and spectinomycin (SPT), cefixime (CFX) and AZM, CFX and DOX, and CFX and SPT was determined using a checkerboard method. The fractional inhibitory concentration index (FICI) values for all combinations were either additive or indifferent, and no synergistic or antagonistic effects were found. The FICI comparison in each combination did not show any difference according to the N.gonorrhoeae-resistant phenotypes and genotypic characteristics, including penicillinase-producing N. gonorrhoeae, tetracycline-resistant N. gonorrhoeae, stratified MIC of all antibiotics, and N. gonorrhoeae multiantigen sequence typing. MIC50 and MIC90 of tigecycline by agar dilution were 0.5 mg/L and 0.5 mg/L, respectively, which were lower than that of tetracycline and DOX. Additive/indifference results could suggest that combinations that include CRO may be used safely without a significant likelihood of generating resistance.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889316303650
DOI
10.1016/j.diagmicrobio.2016.10.022
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
이혁민(Lee, Hyuk Min) ORCID logo https://orcid.org/0000-0002-8523-4126
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154282
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