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Serum anti-lysozyme is associated with disease activity of Behçet's disease

Authors
 Jin-Su Park  ;  Mi-Il Kang  ;  You-Jung Ha  ;  Jason Jungsik Song  ;  Yong-Beom Park  ;  Soo-Kon Lee  ;  Sang-Won Lee 
Citation
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.20(2) : 261-268, 2017 
Journal Title
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 
ISSN
 1756-1841 
Issue Date
2017
MeSH
Adult ; Aged ; Autoantibodies/blood* ; Behcet Syndrome/blood* ; Behcet Syndrome/diagnosis ; Behcet Syndrome/enzymology ; Behcet Syndrome/immunology ; Biomarkers/blood ; Chi-Square Distribution ; Female ; Humans ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Muramidase/immunology* ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Severity of Illness Index ; Up-Regulation ; Young Adult
Keywords
BDCAF ; Behçet's disease ; anti-lysozyme ; disease activity
Abstract
OBJECTIVES: We investigated the association between autoantibodies against non-myeloperoxidase (MPO) neutrophil granule antigens and activity of Behçet's disease (BD). METHODS: We consecutively enrolled 51 BD patients. We assessed clinical data and BD activity using patients' index scores from the Behçet's Disease Current Activity Form and we performed tests for antibodies against proteinase 3 (PR3), MPO, bactericidal permeability increasing protein (BPI), cathepsin G, elastase, lactoferrin and lysozyme. RESULTS: The median patient index score was 2.0, and 56.9% of patients had active BD. In multivariate analysis of variables with significant correlations, only anti-lysozyme showed a significant correlation with BD activity (P = 0.002). In multivariate logistic regression analyses of variables, when patients were classified into groups according to the optimal cutoff levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and anti-lysozyme (ESR > 42.5 mm/h, CRP > 1.35 mg/L and anti-lysozyme > 2.95 IU/mL), the variable with independent predictive value was anti-lysozyme (odds ratio 8.384, P = 0.015). CONCLUSION: Anti-lysozyme was significantly correlated with disease activity score and it was the only independent value to predict active disease in patients with BD. Furthermore, patients having anti-lysozyme levels ≥ 2.95 IU/mL had a significantly higher risk of having active BD than those who did not.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/1756-185X.12832/abstract
DOI
10.1111/1756-185X.12832
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Song, Jungsik Jason(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Lee, Sang Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154272
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