Cited 8 times in
Efficacy and tolerability of preservative-free 0.0015% tafluprost in glaucoma patients: a prospective crossover study
DC Field | Value | Language |
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dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 배형원 | - |
dc.contributor.author | 성공제 | - |
dc.date.accessioned | 2017-11-02T08:14:57Z | - |
dc.date.available | 2017-11-02T08:14:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154250 | - |
dc.description.abstract | BACKGROUND: The aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost using a prospective crossover study. METHODS: Primary open angle glaucoma (POAG) and normotensive glaucoma (NTG) patients were randomized enrolled. Group 1 ("NPT to PT") patients used preservative-free 0.0015% tafluprost (NPT) for 6 months and then changed to preservative containing 0.0015% tafluprost(PT) for 6 months. Group 2 ("PT to NPT") patients used preservative containing 0.0015% tafluprost for 6 months and changed to preservative-free 0.0015% tafluprost for 6 months. At 1, 3, 6, 7, 9, and 12 months, we measured intraocular pressure for efficacy and graded corneal erosion, tear break-up time (TBUT), and subjective discomfort. RESULTS: A total of 20 patients and 20 eyes were enrolled. In Group 1 and 2, intraocular pressure was well controlled to approximately 14 mmHg (9.38-18.46% decrease). Generally, subjective satisfaction was improved after changing from PT to NPT (p = 0.03) and TBUT using PT was numerically inferior to that using NPT (p = 0.06) but not when changing from NPT to PT. CONCLUSION: Both preservative containing and preservative-free 0.0015% tafluprost reduced intraocular pressure significantly. In addition, changing medication from PT to NPT might improve subjective satisfaction and tear break up time. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cross-Over Studies | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Tolerance* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glaucoma/drug therapy* | - |
dc.subject.MESH | Glaucoma/physiopathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraocular Pressure/drug effects* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ophthalmic Solutions/administration & dosage | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Prostaglandins F/administration & dosage* | - |
dc.subject.MESH | Tonometry, Ocular | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Efficacy and tolerability of preservative-free 0.0015% tafluprost in glaucoma patients: a prospective crossover study | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Wonseok Lee | - |
dc.contributor.googleauthor | Sunghoon Lee | - |
dc.contributor.googleauthor | HyoungWon Bae | - |
dc.contributor.googleauthor | Chan Yun Kim | - |
dc.contributor.googleauthor | Gong Je Seong | - |
dc.identifier.doi | 10.1186/s12886-017-0453-z | - |
dc.contributor.localId | A01814 | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A01035 | - |
dc.relation.journalcode | J00370 | - |
dc.identifier.eissn | 1471-2415 | - |
dc.relation.journalsince | 2001~ | - |
dc.identifier.pmid | 28454526 | - |
dc.subject.keyword | Efficacy | - |
dc.subject.keyword | Preservative | - |
dc.subject.keyword | Tafluprost | - |
dc.subject.keyword | Tolerability | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.alternativeName | Bae, Hyoung Won | - |
dc.contributor.alternativeName | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Bae, Hyoung Won | - |
dc.contributor.affiliatedAuthor | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Kim, Chan Yun | - |
dc.citation.title | BMC Ophthalmology | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 61 | - |
dc.citation.endPage | 68 | - |
dc.identifier.bibliographicCitation | BMC OPHTHALMOLOGY, Vol.17(1) : 61-68, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42219 | - |
dc.type.rims | ART | - |
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