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RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

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dc.contributor.author박종철-
dc.date.accessioned2017-11-02T08:13:43Z-
dc.date.available2017-11-02T08:13:43Z-
dc.date.issued2017-
dc.identifier.issn2056-3418-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154224-
dc.description.abstractIn recent years, much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular behaviors. In our study, RGD peptide and graphene oxide (GO) co-functionalized poly(lactide-co-glycolide, PLGA) (RGD-GO-PLGA) nanofiber mats were fabricated via electrospinning, and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue engineering. Scanning electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of random-oriented electrospun nanofibers with average diameter of 558 nm. The successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic analysis. Moreover, the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and GO. It was found that the mats were thermally stable under the cell culture condition. Furthermore, the initial attachment and proliferation of primarily cultured vascular smooth muscle cells (VSMCs) on the RGD-GO-PLGA nanofiber mats were evaluated. It was revealed that the RGD-GO-PLGA nanofiber mats can effectively promote the growth of VSMCs. In conclusion, our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press in association with the Chinese Society for Biomaterials-
dc.relation.isPartOfRegenerative Biomaterials-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Medical Engineering-
dc.contributor.googleauthorYong Cheol Shin-
dc.contributor.googleauthorJeonghyo Kim-
dc.contributor.googleauthorSung Eun Kim-
dc.contributor.googleauthorSu-Jin Song-
dc.contributor.googleauthorSuck Won Hong-
dc.contributor.googleauthorJin-Woo Oh-
dc.contributor.googleauthorJaebeom Lee-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorSuong-Hyu Hyon-
dc.contributor.googleauthorDong-Wook Han-
dc.identifier.doi10.1093/rb/rbx001-
dc.contributor.localIdA01662-
dc.relation.journalcodeJ03101-
dc.relation.journalsince2014-
dc.identifier.urlhttps://academic.oup.com/rb/article/4/3/159/2972206/RGD-peptide-and-graphene-oxide-co-functionalized-
dc.subject.keywordRGD peptide-
dc.subject.keywordbiofunctional scaffold-
dc.subject.keywordgraphene oxide-
dc.subject.keywordpoly(lactic-co-glycolic acid)-
dc.subject.keywordvascular smooth muscle cell-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.citation.titleRegenerative Biomaterials-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPage159-
dc.citation.endPage166-
dc.identifier.bibliographicCitationRegenerative Biomaterials, Vol.4(3) : 159-166, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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