Cited 67 times in
RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.date.accessioned | 2017-11-02T08:13:43Z | - |
dc.date.available | 2017-11-02T08:13:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2056-3418 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154224 | - |
dc.description.abstract | In recent years, much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular behaviors. In our study, RGD peptide and graphene oxide (GO) co-functionalized poly(lactide-co-glycolide, PLGA) (RGD-GO-PLGA) nanofiber mats were fabricated via electrospinning, and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue engineering. Scanning electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of random-oriented electrospun nanofibers with average diameter of 558 nm. The successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic analysis. Moreover, the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and GO. It was found that the mats were thermally stable under the cell culture condition. Furthermore, the initial attachment and proliferation of primarily cultured vascular smooth muscle cells (VSMCs) on the RGD-GO-PLGA nanofiber mats were evaluated. It was revealed that the RGD-GO-PLGA nanofiber mats can effectively promote the growth of VSMCs. In conclusion, our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press in association with the Chinese Society for Biomaterials | - |
dc.relation.isPartOf | REGENERATIVE BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Medical Engineering | - |
dc.contributor.googleauthor | Yong Cheol Shin | - |
dc.contributor.googleauthor | Jeonghyo Kim | - |
dc.contributor.googleauthor | Sung Eun Kim | - |
dc.contributor.googleauthor | Su-Jin Song | - |
dc.contributor.googleauthor | Suck Won Hong | - |
dc.contributor.googleauthor | Jin-Woo Oh | - |
dc.contributor.googleauthor | Jaebeom Lee | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.contributor.googleauthor | Suong-Hyu Hyon | - |
dc.contributor.googleauthor | Dong-Wook Han | - |
dc.identifier.doi | 10.1093/rb/rbx001 | - |
dc.contributor.localId | A01662 | - |
dc.relation.journalcode | J03101 | - |
dc.identifier.eissn | 2056-3426 | - |
dc.relation.journalsince | 2014 | - |
dc.identifier.url | https://academic.oup.com/rb/article/4/3/159/2972206/RGD-peptide-and-graphene-oxide-co-functionalized | - |
dc.subject.keyword | RGD peptide | - |
dc.subject.keyword | biofunctional scaffold | - |
dc.subject.keyword | graphene oxide | - |
dc.subject.keyword | poly(lactic-co-glycolic acid) | - |
dc.subject.keyword | vascular smooth muscle cell | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.citation.title | Regenerative Biomaterials | - |
dc.citation.volume | 4 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 159 | - |
dc.citation.endPage | 166 | - |
dc.identifier.bibliographicCitation | REGENERATIVE BIOMATERIALS, Vol.4(3) : 159-166, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42193 | - |
dc.type.rims | ART | - |
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