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Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for appendiceal and colorectal cancer with peritoneal carcinomatosis: Clinical outcomes at 2 tertiary referral centers in Korea

Authors
 Eun Jung Park  ;  Seung Hyuk Baik  ;  Hyuk Hur  ;  Byung Soh Min  ;  Jeonghyun Kang  ;  Yun Dae Han  ;  Min Soo Cho  ;  Kang Young Lee  ;  Nam Kyu Kim 
Citation
 MEDICINE, Vol.96(21) : 6632, 2017 
Journal Title
 MEDICINE 
ISSN
 0025-7974 
Issue Date
2017
MeSH
Antineoplastic Agents/administration & dosage ; Appendiceal Neoplasms/pathology ; Appendiceal Neoplasms/therapy* ; Carcinoma/pathology ; Carcinoma/therapy* ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy* ; Combined Modality Therapy ; Cytoreduction Surgical Procedures* ; Feasibility Studies ; Female ; Humans ; Hyperthermia, Induced* ; Injections, Intraperitoneal ; Length of Stay ; Male ; Middle Aged ; Neoplasm Grading ; Operative Time ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/therapy* ; Postoperative Complications ; Prospective Studies ; Republic of Korea ; Tertiary Care Centers ; Treatment Outcome
Keywords
appendiceal neoplasms ; colorectal neoplasms ; cytoreduction surgical procedures ; injections ; intraperitoneal ; peritoneal neoplasms
Abstract
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is regarded as effective surgical treatments in patients with peritoneal metastasis. This study aimed to evaluate the clinical outcomes of CRS and HIPEC in patients with appendiceal or colorectal cancer with peritoneal carcinomatosis.A total of 66 patients who underwent CRS with HIPEC for appendiceal or colorectal cancer with peritoneal metastasis at 2 tertiary referral centers in Korea were evaluated between July 2014 and March 2016. The perioperative outcomes and postoperative complications were evaluated prospectively.The mean peritoneal cancer index (PCI) was 15.3 ± 10.5. The distributions thereof were as follows: PCI < 10, 33.3%; PCI 10-19, 36.4%; and PCI≥20, 30.3%. Regarding completeness of cytoreduction (CC), 59.1% of patients achieved CC-0, with 18.2% showing CC-1 and 22.7% showing CC-2. The mean operation time was 9.4 hours, and the mean hospital stay was 20.2 days. The overall rate of short-term complications was 74.2%; the rate of long-term complications was 10.6%. In the short-term period, most complications were grades I-II complications (62.1%), compared to grades III-V (12.1%). All long-term complications, occurring in 10.6% of patients, were grades III-V.In this study, CRS with HIPEC was deemed feasible and safe for treating stage IV appendiceal or colorectal cancer with peritoneal carcinomatosis in Koreans.
Files in This Item:
T201701870.pdf Download
DOI
10.1097/MD.0000000000006632
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jeonghyun(강정현) ORCID logo https://orcid.org/0000-0001-7311-6053
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Park, Eun Jung(박은정) ORCID logo https://orcid.org/0000-0002-4559-2690
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Lee, Kang Young(이강영)
Cho, Min Soo(조민수)
Han, Yoon Dae(한윤대) ORCID logo https://orcid.org/0000-0002-2136-3578
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154214
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