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Prevalence and severity of coronary artery calcification based on the epidemiologic pattern: A propensity matched comparison of asymptomatic Korean and Chinese adults

Authors
 Donghee Han  ;  Yang Gao  ;  Bríain ó Hartaigh  ;  Heidi Gransar  ;  Ji Hyun Lee  ;  Asim Rizvi  ;  Su-Yeon Choi  ;  Eun Ju Chun  ;  Jidong Sung  ;  Hae-Won Han  ;  Sung Hak Park  ;  James K. Min  ;  Bin Lu  ;  Hyuk-Jae Chang 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.230 : 353-358, 2017 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2017
MeSH
China/epidemiology ; Coronary Angiography/methods* ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology* ; Coronary Vessels/diagnostic imaging* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Odds Ratio ; Predictive Value of Tests ; Prevalence ; Propensity Score* ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment/methods* ; Risk Factors ; Severity of Illness Index ; Time Factors ; Tomography, X-Ray Computed ; Vascular Calcification/diagnosis ; Vascular Calcification/epidemiology*
Keywords
Coronary artery calcium score ; Coronary artery disease ; East Asian ; Epidemiology ; Risk factors
Abstract
BACKGROUND: Lifestyle, environmental, and genetic factors substantially influence cardiovascular disease (CVD) risk. We aimed to explore epidemiologic trends in coronary artery calcium scores (CACS), as a marker of CVD, along with possible differences by geographic area and study period in separate East Asian populations. METHODS: We generated 3 matched groups (n=702) using a propensity scoring approach derived from a Korean (N=48,901) and Chinese cohort (N=927) as follows: (1) A recent Chinese group and (2) recent Korean group, both of whom underwent CACS scanning from 2012-2014; and (3) a past Korean group who underwent CACS scanning 8-10years before the index group (2002-2006). We used logistic regression to generate odds ratios (OR) with 95% confidence intervals (95% CI) to estimate the likelihood of having CACS between the groups, based on CACS stratified by severity: >0 (any), >100 (moderate), and >400 (severe). RESULTS: The prevalence of any, moderate, or severe CACS did not differ significantly between the recent Chinese and Korean groups. Notably, the odds of the presence of moderate CACS in the recent Chinese group (OR: 3.05, 95% CI: 1.49-6.71, P-value<0.001) and the presence of any CACS in the recent Korean group (OR: 1.58, 95% CI: 1.17-2.15, P-value<0.001) were significantly higher than in the past Korean group. CONCLUSIONS: In this study involving separate East Asian populations, there were no geographic differences in the prevalence of CACS. However, changes in other unmeasured factors over time are likely the culprits for the elevated prevalence of CACS in asymptomatic East Asians.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527316345971
DOI
10.1016/j.ijcard.2016.12.106
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jee Hyun(이지현)
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Han, Donghee(한동희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154192
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