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Fecal Calprotectin Level Reflects the Severity of Clostridium difficile Infection

Authors
 Jieun Kim  ;  Heejung Kim  ;  Hyun Ju Oh  ;  Hyung Sun Kim  ;  Youn Jee Hwang  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Kyungwon Lee 
Citation
 Annals of Laboratory Medicine, Vol.37(1) : 53-57, 2017 
Journal Title
 Annals of Laboratory Medicine 
ISSN
 2234-3806 
Issue Date
2017
MeSH
Aged ; Area Under Curve ; Biomarkers/analysis ; Clostridium difficile/isolation & purification* ; Enterocolitis, Pseudomembranous/diagnosis ; Enterocolitis, Pseudomembranous/microbiology ; Enterocolitis, Pseudomembranous/pathology* ; Enzyme-Linked Immunosorbent Assay ; Feces/chemistry* ; Female ; Humans ; Leukocyte L1 Antigen Complex/analysis* ; Male ; Middle Aged ; ROC Curve ; Severity of Illness Index
Keywords
Clostridium difficile infection ; Fecal calprotectin ; Severity assessment
Abstract
Clostridium difficile is a significant nosocomial and community-acquired pathogen, and is the leading cause of antibiotic-induced diarrhea associated with high morbidity and mortality. Given that the treatment outcome depends on the severity of C. difficile infection (CDI), we aimed to establish an efficient method of assessing severity, and focused on the stool biomarker fecal calprotectin (FC). FC directly reflects the intestinal inflammation status of a patient, and can aid in interpreting the current guidelines, which requires the integration of indirect laboratory parameters. The distinction of 80 patients with CDI versus 71 healthy controls and 30 severe infection cases versus 50 mild cases was possible using FC as a marker. The area under the receiver operating characteristic curves were 0.821 and 0.746 with a sensitivity of 75% and 70% and specificity of 79% and 80%, for severe versus mild cases, respectively. We suggest FC as a predictive marker for assessing CDI severity, which is expected to improve the clinical management of CDI.
Files in This Item:
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DOI
10.3343/alm.2017.37.1.53
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김지은(Kim, Jieun)
김희정(Kim, Heejung) ORCID logo https://orcid.org/0000-0002-0190-703X
오현주(Oh, Hyun Ju)
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154175
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