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High recurrence of atrial fibrillation in patients with high tissue atrial natriuretic peptide and amyloid levels after concomitant maze and mitral valve surgery

Authors
 Junbeom Park  ;  Seung Hyun Lee  ;  Jihei Sara Lee  ;  Jae Hyung Park  ;  Boyoung Joung  ;  Moon-Hyoung Lee  ;  Byung-Chul Chang  ;  Hui-Nam Pak 
Citation
 Journal of Cardiology, Vol.69(1) : 345-352, 2017 
Journal Title
 Journal of Cardiology 
ISSN
 0914-5087 
Issue Date
2017
MeSH
Aged ; Amyloid/analysis* ; Atrial Fibrillation/physiopathology* ; Atrial Fibrillation/surgery ; Atrial Natriuretic Factor/analysis* ; Biomarkers/analysis ; Cardiac Surgical Procedures/methods ; Female ; Fibrosis ; Heart Atria/pathology ; Heart Atria/surgery ; Hemodynamics/physiology* ; Humans ; Male ; Middle Aged ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Postoperative Period ; Recurrence
Keywords
Amyloid ; Atrial natriuretic peptide ; Maze surgery ; Valvular atrial fibrillation
Abstract
BACKGROUND: Hemodynamic burden is thought to play a role in valvular atrial fibrillation (AF), but the detailed pathophysiology is unclear. We hypothesized that atrial natriuretic peptide (ANP) tissue levels and amyloid deposits in the left atrial appendage (LAA) were associated with the pre-operative hemodynamic status and post-operative rhythm outcome in patients undergoing a concomitant mitral valve and maze surgery. METHODS: We quantified the fibrosis, atrial amyloid deposits, ANP tissue levels, and multiple biomarker proteins (Western blot) in LAA tissues taken from 26 patients (53.8% male, 58.4±9.7 years) who underwent concomitant maze and mitral valve surgery. The histologic and biochemical results were compared with the pre-operative pulmonary artery pressure (PAP) and post-operative rhythm outcome. RESULTS: The ANP tissue level was positively correlated with the atrial amyloid deposit areas (R=0.880, p<0.001), but not with the degree of fibrosis. The pre-operative systolic PAP negatively correlated with both the ANP tissue expression level (R=-0.467, p=0.019) and atrial amyloid deposit area (R=-0.589, p=0.008). The angiotensin II tissue expression level was significantly higher in tissues without ANP expression than in those with expression (p=0.003). AF recurrence after the maze operation was significantly lower in patients without than in those with ANP expression (log rank p=0.031, HR 3.779, 95% CI 1.163-12.277, p=0.027). CONCLUSIONS: A lower ANP atrial tissue expression and amyloid deposits were correlated with a high pre-operative hemodynamic loading, and those patients had a paradoxically lower AF recurrence after relief of the hemodynamic burden by concomitant maze and mitral valve surgery.
Full Text
http://www.sciencedirect.com/science/article/pii/S0914508716301599
DOI
10.1016/j.jjcc.2016.07.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
박준범(Park, Jun Beom)
박희남(Pak, Hui Nam) ORCID logo https://orcid.org/0000-0002-3256-3620
이문형(Lee, Moon Hyoung) ORCID logo https://orcid.org/0000-0002-7268-0741
이승현(Lee, Seung Hyun) ORCID logo https://orcid.org/0000-0002-0311-6565
장병철(Chang, Byung Chul)
정보영(Joung, Bo Young) ORCID logo https://orcid.org/0000-0001-9036-7225
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154163
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