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Correlation between change in muscle excursion and collagen content after tendon rupture and delayed repair

Authors
 Il-Hyun Koh  ;  Ho-Jung Kang  ;  Won-Taek Oh  ;  Jung-Jun Hong  ;  Yun-Rak Choi 
Citation
 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, Vol.12(15) : 1-7, 2017 
Journal Title
 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 
Issue Date
2017
Keywords
Collagen subtypes ; Delayed tendon repair ; Muscle excursion ; Tendon rupture
Abstract
BACKGROUND: The objectives of the present study were to compare changes in muscle excursion, total collagen, and collagen subtypes after tenotomy over time and after delayed tendon repair. METHODS: Tenotomy on the extensor digitorum tendon of the right second toes of 48 New Zealand White rabbits was performed; toes on the left leg were used as controls. Passive muscle excursion, total collagen content, and type I, III, and IV collagen contents were measured at 1, 2, 4, and 6 weeks after tenotomy. Next, passive muscle excursion and total collagen content were measured at 8 weeks after delayed tendon repair at 1, 2, 4, and 6 weeks after a tenotomy. RESULTS: Passive muscle excursion decreased sequentially over time after tenotomy. Meanwhile, total collagen increased over time. These changes were significant after 4 weeks of injury. Type I collagen significantly increased, type III collagen significantly decreased, and type IV collagen had no significant change over time. Passive muscle excursion was negatively correlated with total collagen and type I collagen after tenotomy at each time point after tenotomy (p < 0.05). After tendon repair, increases in total collagen content after tenotomy were not reversed, despite early repairs at 1 and 2 weeks after tenotomy. CONCLUSIONS: Increases in type I collagen were found to be associated with decreased excursion after tendon rupture. The increase in collagen that was observed after tenotomy was not reversed by repair within 8 weeks.
Files in This Item:
T201700195.pdf Download
DOI
10.1186/s13018-017-0518-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ho Jung(강호정) ORCID logo https://orcid.org/0000-0003-0273-1264
Koh, Il Hyun(고일현) ORCID logo https://orcid.org/0000-0001-9823-8516
Oh, Won Taek(오원택) ORCID logo https://orcid.org/0000-0003-1815-0851
Choi, Yun Rak(최윤락)
Hong, Jung Jun(홍정준) ORCID logo https://orcid.org/0000-0003-1715-1190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154141
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