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Analysis of the Clinicopathological Characteristics of Gastric Cancer in Extremely Old Patients

 Il Woong Sohn  ;  Da Hyun Jung  ;  Jie-Hyun Kim  ;  Hyun Soo Chung  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
 CANCER RESEARCH AND TREATMENT, Vol.49(1) : 204-212, 2017 
Journal Title
Issue Date
Age Factors ; Aged, 80 and over ; Comorbidity ; Female ; Humans ; Male ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Patient Outcome Assessment ; Prognosis ; Stomach Neoplasms/diagnosis* ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Survival Rate ; Symptom Assessment ; Tumor Burden
Aged ; Oldest old ; Stomach neoplasms ; Therapy
PURPOSE: Gastric cancer is the third-leading cause of cancer-related death in Korea. As the Korean population is ageing, the number of extremely old patients with this disease is increasing. This study examined the clinicopathological characteristics of gastric cancer in extremely old (over 85 years) patients who received treatment or conservative observations and compared the treatment outcomes according to the treatment modality.

MATERIALS AND METHODS: A total of 170 patients over 85 years of age were diagnosed with gastric cancer. Of these, 81 underwent treatment for gastric cancer and 89 received conservative observations. The clinicopathological characteristics of the treatment and conservative groupswere compared.

RESULTS: The mean age of the patients was 86.5 years. The conservative group included significantly more patients with older ages, macroscopically advanced cancer and upper-middle located cancer. The overall survival rate of the treatment group was significantly higher than that of the conservative group. The disease-specific mortality rate was significantly lower in the treatment group than in the conservative group. Multivariate analysis revealed the clinical course, alarm sign, and macroscopic classification to be independent prognosis factors.

CONCLUSION: By itself, the chronological age should not be used as a strategy to determine whether treatmentwill be administered for gastric cancer. Patients who have early gastric cancer or lower-risk preexisting comorbidities should not be discouraged from treatment, even if they are older than 85 years.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Sohn, Il Woong(손일웅)
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Jung, Da Hyun(정다현) ORCID logo https://orcid.org/0000-0001-6668-3113
Chung, Hyun Soo(정현수)
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