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The Effects of Intravenous Lidocaine Infusions on the Quality of Recovery and Chronic Pain After Robotic Thyroidectomy: A Randomized, Double-Blinded, Controlled Study

 Kwan Woong Choi  ;  Kee-Hyun Nam  ;  Jeong-Rim Lee  ;  Woong Youn Chung  ;  Sang-Wook Kang  ;  Young Eun Joe  ;  Jae Hoon Lee 
 World Journal of Surgery, Vol.41(5) : 1305-1312, 2017 
Journal Title
 World Journal of Surgery 
Issue Date
Adult ; Anesthetics, Local/therapeutic use* ; Chronic Pain/prevention & control* ; Double-Blind Method ; Female ; Humans ; Infusions, Intravenous ; Lidocaine/therapeutic use* ; Male ; Pain Measurement ; Pain, Postoperative/prevention & control* ; Robotic Surgical Procedures ; Thyroidectomy*
Lidocaine ; Sensory Disturbance ; Endoscopic Thyroidectomy ; Robotic Thyroidectomy ; Ramosetron
BACKGROUND: The effect of the systemic lidocaine on postoperative recovery has not been definitively investigated despite its analgesic efficacy after surgery. The aim of this randomized, double-blinded, controlled study was to evaluate the effect of intravenously administered lidocaine on the quality of recovery and on acute and chronic postoperative pain after robot-assisted thyroidectomy. METHODS: Ninety patients who were undergoing robotic thyroidectomy were randomly assigned to the lidocaine or the control groups. The patients received 2 mg/kg of lidocaine followed by continuous infusions of 3 mg/kg/h of lidocaine (Group L) or the same volume of 0.9% normal saline (Group C) intravenously during anesthesia. The acute pain profiles and the quality of recovery, which was assessed using the quality of recovery-40 questionnaire (QoR-40), were evaluated for 2 days postoperatively. Chronic postsurgical pain (CPSP) and sensory disturbances at the surgical sites were evaluated 3 months after surgery. RESULTS: The QoR-40 and pain scores that were assessed during the 2 days that followed surgery were largely comparable between the groups. However, CPSP was more prevalent in the Group C than in the Group L (16/43 vs. 6/41; p = 0.025). The tactile sensory score 3 months after the operation was significantly greater in the Group L than in the Group C (7 vs. 5; p = 0.001). CONCLUSION: Systemic lidocaine administration was associated with reductions in CPSP and sensory impairment after robot-assisted thyroidectomy although it was not able to reduce acute postsurgical pain or improve the quality of recovery. Trial registry number NCT01907997 ( http://clinicaltrials.gov ).
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
강상욱(Kang, Sang Wook) ORCID logo https://orcid.org/0000-0001-5355-833X
남기현(Nam, Kee Hyun) ORCID logo https://orcid.org/0000-0002-6852-1190
이재훈(Lee, Jae Hoon) ORCID logo https://orcid.org/0000-0001-6679-2782
이정림(Lee, Jeong Rim) ORCID logo https://orcid.org/0000-0002-7425-0462
정웅윤(Chung, Woung Youn)
조영은(Joe, Young Eun) ORCID logo https://orcid.org/0000-0002-5848-5843
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