Cited 20 times in

Efficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials

DC Field Value Language
dc.contributor.author김지혜-
dc.contributor.author김학선-
dc.contributor.author문성환-
dc.contributor.author석경수-
dc.contributor.author양재호-
dc.contributor.author이환모-
dc.contributor.author정우철-
dc.contributor.author강영미-
dc.date.accessioned2017-11-01T08:59:32Z-
dc.date.available2017-11-01T08:59:32Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153882-
dc.description.abstractPURPOSE: Nonsteroidal anti-inflammatory drugs are a mainstay for medical treatment of chronic lower back pain (CLBP). Increased dose intervals for medication have been associated with increased patient adherence to prescriptions. The purpose of this clinical trial was to compare the efficacy and safety of a once daily dose of aceclofenac controlled release (CR) and a twice daily dose of aceclofenac for CLBP management. MATERIALS AND METHODS: A prospective, randomized, single center, open-label clinical trial was performed to compare the efficacy and safety of aceclofenac CR (200 mg once daily) to aceclofenac dose (100 mg twice daily). Fifty patients in each group were enrolled for the study. The primary end point was Visual Analogue Scale (VAS) change at baseline to that at 2 weeks after medication and safety profiles. Also, change in quality of life measured by EuroQoL 5D (EQ-5D) and Oswestry Disability Index (ODI) functional score for the lumbar spine were also assessed. RESULTS: Within groups at pre- and post-treatment, there were significant VAS reductions for aceclofenac CR and aceclofenac (p=0.028). EQ-5D increased significantly in both groups (p=0.037). ODI scores decreased significantly in both groups (p=0.012). However, there were no significant differences between aceclofenac CR and aceclofenac at pre- and post-treatment. Patients with aceclofenac CR showed significant increases in heartburn and indigestion and adverse gastrointestinal effects, compared to aceclofenac. CONCLUSION: In patients with CLBP, aceclofenac CR and aceclofenac demonstrated significant symptomatic pain relief, improvement in quality of life and functional scores. Aceclofenac CR slightly increased gastrointestinal adverse effects, such as heartburn and indigestion.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/administration & dosage*-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/therapeutic use-
dc.subject.MESHDiclofenac/administration & dosage-
dc.subject.MESHDiclofenac/analogs & derivatives*-
dc.subject.MESHDiclofenac/therapeutic use-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLow Back Pain/drug therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement-
dc.subject.MESHProspective Studies-
dc.subject.MESHQuality of Life-
dc.subject.MESHTreatment Outcome-
dc.titleEfficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentYonsei Biomedical Research Center-
dc.contributor.googleauthorJae-Ho Yang-
dc.contributor.googleauthorKyung-Soo Suk-
dc.contributor.googleauthorByung-Ho Lee-
dc.contributor.googleauthorWoo-Chul Jung-
dc.contributor.googleauthorYoung-Mi Kang-
dc.contributor.googleauthorJi-Hye Kim-
dc.contributor.googleauthorHak-Sun Kim-
dc.contributor.googleauthorHwan-Mo Lee-
dc.contributor.googleauthorSeong-Hwan Moon-
dc.identifier.doi10.3349/ymj.2017.58.3.637-
dc.contributor.localIdA01093-
dc.contributor.localIdA01365-
dc.contributor.localIdA01926-
dc.contributor.localIdA02317-
dc.contributor.localIdA03333-
dc.contributor.localIdA04671-
dc.contributor.localIdA01001-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28332372-
dc.subject.keywordChronic lower back pain-
dc.subject.keywordNSAIDs-
dc.subject.keywordaceclofenac-
dc.contributor.alternativeNameKim, Ji Hye-
dc.contributor.alternativeNameKim, Hak Sun-
dc.contributor.alternativeNameMoon, Seong Hwan-
dc.contributor.alternativeNameSuk, Kyung Soo-
dc.contributor.alternativeNameYang, Jae Ho-
dc.contributor.alternativeNameLee, Hwan Mo-
dc.contributor.alternativeNameJung, Woo Chul-
dc.contributor.affiliatedAuthorKim, Hak Sun-
dc.contributor.affiliatedAuthorMoon, Seong Hwan-
dc.contributor.affiliatedAuthorSuk, Kyung Soo-
dc.contributor.affiliatedAuthorYang, Jae Ho-
dc.contributor.affiliatedAuthorLee, Hwan Mo-
dc.contributor.affiliatedAuthorJung, Woo Chul-
dc.contributor.affiliatedAuthorKim, Ji Hye-
dc.citation.titleYonsei Medical Journal-
dc.citation.volume58-
dc.citation.number3-
dc.citation.startPage637-
dc.citation.endPage643-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(3) : 637-643, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43643-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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