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Cytogenetic profiles of 2806 patients with acute myeloid leukemia-a retrospective multicenter nationwide study

Authors
 Ja Min Byun  ;  Young Jin Kim  ;  Hwi-Joong Yoon  ;  Si-Young Kim  ;  Hee-Je Kim  ;  Jaeho Yoon  ;  Yoo Hong Min  ;  Jun-Won Cheong  ;  Jinny Park  ;  Jae Hoon Lee  ;  Dae Sik Hong  ;  Seong Kyu Park  ;  Hyeoung-Joon Kim  ;  Jae-Sook Ahn  ;  Ho-Jin Shin  ;  Joo Seop Chung  ;  Won Sik Lee  ;  Sang Min Lee  ;  Yong Park  ;  Byung Soo Kim  ;  Je-Hwan Lee  ;  Kyoo-Hyung Lee  ;  Chul Won Jung  ;  Jun Ho Jang  ;  Woo-Sung Min  ;  Tae Sung Park 
Citation
 Annals of Hematology, Vol.95(8) : 1223-1232, 2016 
Journal Title
 Annals of Hematology 
ISSN
 0939-5555 
Issue Date
2016
Abstract
The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n?=?45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.
Full Text
https://link.springer.com/article/10.1007%2Fs00277-016-2691-1
DOI
10.1007/s00277-016-2691-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153072
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