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Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry

 Seung Jin Han  ;  Kyung-Soo Kim  ;  Wonjin Kim  ;  Jung Hee Kim  ;  Yong-ho Lee  ;  Ji Sun Nam  ;  Ji A Seo  ;  Bu Kyung Kim  ;  Jihyun Lee  ;  Jin Ook Chung  ;  Min-Hee Kim  ;  Tae-Seo Sohn  ;  Han Seok Choi  ;  Seong Bin Hong  ;  Yoon-Sok Chung 
 Endocrinology and Metabolism (대한내분비학회지), Vol.31(4) : 598-603, 2016 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
Issue Date
BACKGROUND: The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.

METHODS: Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.

RESULTS: Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m²) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.

CONCLUSION: Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
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