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Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2017-10-26T08:07:29Z | - |
dc.date.available | 2017-10-26T08:07:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-2467 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152991 | - |
dc.description.abstract | Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Seo Heung Pub. Co. | - |
dc.relation.isPartOf | Journal of Bacteriology and Virology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Apoptotic Effect of Macrophages against Mycobacterium tuberculosis | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Lee-Han Kim | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.identifier.doi | 10.4167/jbv.2016.46.4.312 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01255 | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 312 | - |
dc.citation.endPage | 318 | - |
dc.identifier.bibliographicCitation | Journal of Bacteriology and Virology, Vol.46(4) : 312-318, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41000 | - |
dc.type.rims | ART | - |
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