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EGF enhances low-invasive cancer cell invasion by promoting IMP-3 expression

Authors
 Xianglan Zhang  ;  Im-hee Jung  ;  Young Sun Hwang 
Citation
 TUMOR BIOLOGY, Vol.37(2) : 2555-2563, 2016 
Journal Title
TUMOR BIOLOGY
ISSN
 1010-4283 
Issue Date
2016
Abstract
The initiation and progression of cancer is closely associated with the tumor microenvironment. The overexpression of oncogenes during tumor growth and progression by stromal stimuli can affect the aggressiveness of the cancer. In this study, in vitro and in vivo studies were performed to examine the role of stromal epidermal growth factor (EGF) in enhancing the invasive potential of in low-invasive cancer. EGF was tested in order to elucidate the specific molecules that participate in increasing the invasive potential of low-invasive cancer cells. EGF stimulation enhanced cancer invasion in an EGF receptor (EGFR)-dependent manner. EGF induced insulin-like growth factor-II mRNA-binding protein-3 (IMP-3) and podoplanin (PDPN) expression, which play an important role in oral squamous cell carcinoma (OSCC) cell invasion. An apparent tumor mass was not observed in the mouse xenograft; however, multiple tumor microfoci were seen in mice injected with IMP-3-overexpressing cells. These results show that EGF stimulates IMP-3 expression, thereby increasing cancer invasion and tumor progression.
Full Text
https://link.springer.com/article/10.1007%2Fs13277-015-4099-2
DOI
10.1007/s13277-015-4099-2
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Zhang, Xiang Lan(장향란)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152898
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