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Tacrolimus-induced, Transplant-associated Thrombotic Microangiopathies after Lung Transplantation

Authors
 Ji Soo Choi  ;  Song Yee Kim  ;  Jin Gu Lee  ;  Soo Jeong Kim  ;  Myung Jin Song  ;  Bo Ra Yoon  ;  Moo Hyun Kim  ;  Moo Suk Park  ;  Hyo Chae Paik 
Citation
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.30(2) : 94-97, 2016 
Journal Title
 Journal of the Korean Society for Transplantation (대한이식학회지) 
ISSN
 1298-1711 
Issue Date
2016
Abstract
We report a case of tacrolimus-induced transplant-associated thrombotic microangiopathies (TA-TMA) after lung transplantation. A 71-year-old man underwent lung transplantation secondary to idiopathic pulmonary fibrosis. After 4 months, he presented with abdominal discomfort and dyspnea, and was diagnosed with hemolytic anemia and thrombocytopenia. Tacrolimus was considered the cause of the TMA. Tacrolimus was stopped and several sessions of plasma exchange were performed immediately after diagnosis of TA-TMA. However, his platelet count did not normalize, gastrointestinal bleeding was recurrent, and severe pneumonia developed, following which he died. TA-TMA are rare but severe, life-threatening complications in lung transplant recipients. Therefore, the possibility of TA-TMA should be considered in posttransplant recipients.
Files in This Item:
T201605517.pdf Download
DOI
10.4285/jkstn.2016.30.2.94
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Moo Hyun(김무현)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Song, Myung Jin(송명진) ORCID logo https://orcid.org/0000-0003-2218-8959
Yoon, Bo Ra(윤보라)
Lee, Jin Gu(이진구)
Choi, Ji Soo(최지수) ORCID logo https://orcid.org/0000-0003-2716-6775
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152857
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