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Tacrolimus-induced, Transplant-associated Thrombotic Microangiopathies after Lung Transplantation

 Ji Soo Choi  ;  Song Yee Kim  ;  Jin Gu Lee  ;  Soo Jeong Kim  ;  Myung Jin Song  ;  Bo Ra Yoon  ;  Moo Hyun Kim  ;  Moo Suk Park  ;  Hyo Chae Paik 
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.30(2) : 94-97, 2016 
Journal Title
 Journal of the Korean Society for Transplantation  (대한이식학회지) 
Issue Date
We report a case of tacrolimus-induced transplant-associated thrombotic microangiopathies (TA-TMA) after lung transplantation. A 71-year-old man underwent lung transplantation secondary to idiopathic pulmonary fibrosis. After 4 months, he presented with abdominal discomfort and dyspnea, and was diagnosed with hemolytic anemia and thrombocytopenia. Tacrolimus was considered the cause of the TMA. Tacrolimus was stopped and several sessions of plasma exchange were performed immediately after diagnosis of TA-TMA. However, his platelet count did not normalize, gastrointestinal bleeding was recurrent, and severe pneumonia developed, following which he died. TA-TMA are rare but severe, life-threatening complications in lung transplant recipients. Therefore, the possibility of TA-TMA should be considered in posttransplant recipients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
김무현(Kim, Moo Hyun)
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김수정(Kim, Soo Jeong) ORCID logo https://orcid.org/0000-0001-8859-3573
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
백효채(Paik, Hyo Chae) ORCID logo https://orcid.org/0000-0001-9309-8235
송명진(Song, Myung Jin) ORCID logo https://orcid.org/0000-0003-2218-8959
윤보라(Yoon, Bo Ra)
이진구(Lee, Jin Gu)
최지수(Choi, Ji Soo) ORCID logo https://orcid.org/0000-0003-2716-6775
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