0 189

Cited 23 times in

Helicobacter pylori blood biomarker for gastric cancer risk in East Asia

Authors
 Hui Cai  ;  Fei Ye  ;  Angelika Michel  ;  Gwen Murphy  ;  Shizuka Sasazuki  ;  Philip R Taylor  ;  You-Lin Qiao  ;  Sue K Park  ;  Keun-Young Yoo  ;  Sun Ha Jee  ;  Eo Rin Cho  ;  Jeongseon Kim  ;  Sheau-Chiann Chen  ;  Christian C Abnet  ;  Shoichiro Tsugane  ;  Qiuyin Cai  ;  Xiao-Ou Shu  ;  Wei Zheng  ;  Michael Pawlita  ;  Meira Epplein 
Citation
 INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol.45(3) : 774-781, 2016 
Journal Title
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
ISSN
 0300-5771 
Issue Date
2016
MeSH
Antibodies, Bacterial/blood* ; Biomarkers/blood ; Case-Control Studies ; Far East/epidemiology ; Female ; Helicobacter Infections/blood* ; Helicobacter Infections/epidemiology ; Helicobacter pylori/isolation & purification* ; Humans ; Incidence ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Prospective Studies ; Risk Factors ; Stomach Neoplasms/blood* ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/microbiology*
Keywords
East Asia ; Helicobacter pylori ; biomarkers ; gastric cancer ; stomach neoplasms
Abstract
BACKGROUND: Incidence and mortality rates for gastric cancer, the fifth most commonly diagnosed and third most deadly cancer worldwide, are highest in East Asia. We sought to identify gastric cancer risk biomarkers among eight prospective studies from China, Japan and Korea. METHODS: This pooled nested case-control study included 1608 incident non-cardia gastric cancer cases and 1958 matched controls. Pre-diagnostic antibody levels to 15 Helicobacter pylori proteins were assessed using multiplex serology. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Sero-positivity to 10 H. pylori antigens (Omp, CagA, VacA, HcpC, HP 0305, GroEL, NapA, HyuA, Cad, HpaA) was associated with a 1.29- to 3.26-fold increase in odds of gastric cancer. Omp and HP 0305 consistently remained associated with gastric cancer risk after mutually adjusting for all other markers. Sero-positivity to both Omp and HP 0305 was associated with an over 4-fold increase in gastric cancer incidence (OR, 4.09; 95% CI 3.26-5.13). When limited to only those who are CagA+ H. pylori+, Omp/HP 0305 sero-positivity remained strongly associated with an over 3-fold increase in the odds of gastric cancer (OR, 3.34; 95% CI 2.27-4.91). The results were highly consistent among the cohorts. CONCLUSIONS: We have confirmed new H. pylori biomarkers that are strongly associated with gastric cancer risk, even among those infected with the known H. pylori virulence factor CagA. These results may help to design cost-efficient prevention strategies to reduce gastric cancer incidence in East Asia.
Full Text
https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyw078
DOI
10.1093/ije/dyw078
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152839
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links