Cited 8 times in
Gr-1intCD11b+ myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival
DC Field | Value | Language |
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dc.contributor.author | 김응권 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 이형근 | - |
dc.contributor.author | 지용우 | - |
dc.contributor.author | 최웅락 | - |
dc.date.accessioned | 2017-10-26T08:01:29Z | - |
dc.date.available | 2017-10-26T08:01:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152837 | - |
dc.description.abstract | We identified the characteristics of myeloid-derived suppressor cells (MDSCs) and investigated their mechanism of induction and their functional role in allograft rejection using a murine corneal allograft model. In mice, MDSCs coexpress CD11b and myeloid differentiation antigen Gr-1. Gr-1+CD11b+ cells infiltrated allografted corneas between 4 d and 4 wk after surgery; however, the frequencies of Gr-1+CD11b+ cells were not different between accepted and rejected allografts or in peripheral blood or BM. Of interest, Gr-1intCD11b+ cells, but not Gr-1hiCD11b+ cells, infiltrated the accepted graft early after surgery and expressed high levels of immunosuppressive cytokines, including IL-10, TGF-β, and TNF-related apoptosis-inducing ligand. This population remained until 4 wk after surgery. In vitro, only high dose (>100 ng/ml) of IFN-γ plus GM-CSF could induce immunosuppressive cytokine expression in Gr-1intCD11b+ cells. Furthermore, adoptive transfer of Gr-1intCD11b+ cells reduced T cell infiltration, which improved graft survival. In conclusion, high-dose IFN-γ in allograft areas is essential for development of Gr-1intCD11b+ MDSCs in corneal allografts, and subtle environmental changes in the early period of the allograft can result in a large difference in graft survival. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Society for Leukocyte Biology | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adoptive Transfer | - |
dc.subject.MESH | Allografts/immunology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Ly/analysis | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | CD11b Antigen/analysis | - |
dc.subject.MESH | Corneal Transplantation* | - |
dc.subject.MESH | Cytokines/biosynthesis | - |
dc.subject.MESH | Graft Enhancement, Immunologic/methods* | - |
dc.subject.MESH | Graft Rejection/immunology | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Interferon-gamma/pharmacology | - |
dc.subject.MESH | Lymphocyte Subsets/cytology | - |
dc.subject.MESH | Lymphocyte Subsets/immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Myeloid-Derived Suppressor Cells/classification | - |
dc.subject.MESH | Myeloid-Derived Suppressor Cells/immunology* | - |
dc.subject.MESH | Myeloid-Derived Suppressor Cells/transplantation | - |
dc.subject.MESH | Radiation Chimera | - |
dc.title | Gr-1intCD11b+ myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Wungrak Choi | - |
dc.contributor.googleauthor | Yong Woo Ji | - |
dc.contributor.googleauthor | Hwa-Yong Ham | - |
dc.contributor.googleauthor | Areum Yeo | - |
dc.contributor.googleauthor | Hyemi Noh | - |
dc.contributor.googleauthor | Su-Eon Jin | - |
dc.contributor.googleauthor | Jong Suk Song | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Eung Kwon Kim | - |
dc.contributor.googleauthor | Hyung Keun Lee | - |
dc.identifier.doi | 10.1189/jlb.5A1115-508RR | - |
dc.contributor.localId | A00831 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A03303 | - |
dc.contributor.localId | A03967 | - |
dc.relation.journalcode | J01559 | - |
dc.identifier.eissn | 1938-3673 | - |
dc.identifier.pmid | 27370015 | - |
dc.identifier.url | http://www.jleukbio.org/content/100/6/1453.long | - |
dc.subject.keyword | TNF-related apoptosis-inducing ligand (TRAIL) | - |
dc.subject.keyword | adoptive transfer | - |
dc.subject.keyword | interferon-γ (IFN-γ) | - |
dc.subject.keyword | keratoplasty | - |
dc.subject.keyword | myeloid differentiation antigen Gr-1 | - |
dc.contributor.alternativeName | Kim, Eung Kweon | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.alternativeName | Ji, Yong Woo | - |
dc.contributor.affiliatedAuthor | Kim, Eung Kweon | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | Lee, Hyung Keun | - |
dc.contributor.affiliatedAuthor | Ji, Yong Woo | - |
dc.citation.volume | 100 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1453 | - |
dc.citation.endPage | 1463 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, Vol.100(6) : 1453-1463, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 40467 | - |
dc.type.rims | ART | - |
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