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Gr-1intCD11b+ myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival

DC FieldValueLanguage
dc.contributor.author김응권-
dc.contributor.author김현창-
dc.contributor.author이형근-
dc.contributor.author지용우-
dc.contributor.author최웅락-
dc.date.accessioned2017-10-26T08:01:29Z-
dc.date.available2017-10-26T08:01:29Z-
dc.date.issued2016-
dc.identifier.issn0741-5400-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152837-
dc.description.abstractWe identified the characteristics of myeloid-derived suppressor cells (MDSCs) and investigated their mechanism of induction and their functional role in allograft rejection using a murine corneal allograft model. In mice, MDSCs coexpress CD11b and myeloid differentiation antigen Gr-1. Gr-1+CD11b+ cells infiltrated allografted corneas between 4 d and 4 wk after surgery; however, the frequencies of Gr-1+CD11b+ cells were not different between accepted and rejected allografts or in peripheral blood or BM. Of interest, Gr-1intCD11b+ cells, but not Gr-1hiCD11b+ cells, infiltrated the accepted graft early after surgery and expressed high levels of immunosuppressive cytokines, including IL-10, TGF-β, and TNF-related apoptosis-inducing ligand. This population remained until 4 wk after surgery. In vitro, only high dose (>100 ng/ml) of IFN-γ plus GM-CSF could induce immunosuppressive cytokine expression in Gr-1intCD11b+ cells. Furthermore, adoptive transfer of Gr-1intCD11b+ cells reduced T cell infiltration, which improved graft survival. In conclusion, high-dose IFN-γ in allograft areas is essential for development of Gr-1intCD11b+ MDSCs in corneal allografts, and subtle environmental changes in the early period of the allograft can result in a large difference in graft survival.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSociety for Leukocyte Biology-
dc.relation.isPartOfJournal of Leukocyte Biology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdoptive Transfer-
dc.subject.MESHAllografts/immunology-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, Ly/analysis-
dc.subject.MESHApoptosis-
dc.subject.MESHCD11b Antigen/analysis-
dc.subject.MESHCorneal Transplantation*-
dc.subject.MESHCytokines/biosynthesis-
dc.subject.MESHGraft Enhancement, Immunologic/methods*-
dc.subject.MESHGraft Rejection/immunology-
dc.subject.MESHGraft Survival-
dc.subject.MESHGranulocyte-Macrophage Colony-Stimulating Factor/pharmacology-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHInterferon-gamma/pharmacology-
dc.subject.MESHLymphocyte Subsets/cytology-
dc.subject.MESHLymphocyte Subsets/immunology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMyeloid-Derived Suppressor Cells/classification-
dc.subject.MESHMyeloid-Derived Suppressor Cells/immunology*-
dc.subject.MESHMyeloid-Derived Suppressor Cells/transplantation-
dc.subject.MESHRadiation Chimera-
dc.titleGr-1intCD11b+ myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorWungrak Choi-
dc.contributor.googleauthorYong Woo Ji-
dc.contributor.googleauthorHwa-Yong Ham-
dc.contributor.googleauthorAreum Yeo-
dc.contributor.googleauthorHyemi Noh-
dc.contributor.googleauthorSu-Eon Jin-
dc.contributor.googleauthorJong Suk Song-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorEung Kwon Kim-
dc.contributor.googleauthorHyung Keun Lee-
dc.identifier.doi10.1189/jlb.5A1115-508RR-
dc.contributor.localIdA00831-
dc.contributor.localIdA01142-
dc.contributor.localIdA03303-
dc.contributor.localIdA03967-
dc.relation.journalcodeJ01559-
dc.identifier.pmid27370015-
dc.identifier.urlhttp://www.jleukbio.org/content/100/6/1453.long-
dc.subject.keywordTNF-related apoptosis-inducing ligand (TRAIL)-
dc.subject.keywordadoptive transfer-
dc.subject.keywordinterferon-γ (IFN-γ)-
dc.subject.keywordkeratoplasty-
dc.subject.keywordmyeloid differentiation antigen Gr-1-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.alternativeNameJi, Yong Woo-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.contributor.affiliatedAuthorJi, Yong Woo-
dc.citation.volume100-
dc.citation.number6-
dc.citation.startPage1453-
dc.citation.endPage1463-
dc.identifier.bibliographicCitationJournal of Leukocyte Biology, Vol.100(6) : 1453-1463, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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