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Tuberculosis, smoking and risk for lung cancer incidence and mortality

Authors
 Seri Hong  ;  Yejin Mok  ;  Christina Jeon  ;  Sun Ha Jee  ;  Jonathan M. Samet 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.139(11) : 2447-2455, 2016 
Journal Title
INTERNATIONAL JOURNAL OF CANCER
ISSN
 0020-7136 
Issue Date
2016
MeSH
Adult ; Cohort Studies ; Female ; Humans ; Incidence ; Lung Neoplasms/epidemiology* ; Lung Neoplasms/etiology ; Lung Neoplasms/microbiology ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Smoking/adverse effects ; Smoking/epidemiology* ; Smoking/mortality ; Tuberculosis/epidemiology* ; Tuberculosis/mortality
Keywords
cohort study ; effect modifier ; lung cancer ; smoking ; tuberculosis
Abstract
Among the exposures associated with risk for lung cancer, a history of tuberculosis (TB) is one potentially important factor, given the high prevalence of TB worldwide. A prospective cohort study was conducted to evaluate the associations of preexisting pulmonary TB with lung cancer incidence and mortality. The cohort consisted of 1,607,710 Korean adults covered by the National Health Insurance System who had a biennial national medical examination during 1997-2000. During up to 16 years of follow-up, there were 12,819 incident cases of lung cancer and 9,562 lung cancer deaths. Using Cox proportional hazards models and controlling for age, cigarette smoking and other covariates, the presence of underlying TB was significantly associated with increased risk for lung cancer incidence (HR 1.37 in men with 95% CI 1.29-1.45; HR 1.49 in women with 95% CI 1.28-1.74) and mortality (HR 1.43 in men with 95% CI 1.34-1.52; HR 1.53 in women with 95% CI 1.28-1.83). We also observed a dose-response relationship between number of cigarettes smoked daily and lung cancer risk. There was no evidence for synergism between a history of TB and smoking. The elevation in risk is relatively modest, particularly in comparison to that from smoking, and a prior history of TB is not likely to be useful risk indicator for clinical purposes. In populations with high prevalence of TB, it can be considered for incorporation into models for lung cancer risk prediction.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ijc.30384/abstract
DOI
10.1002/ijc.30384
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Hong, Se Ri(홍세리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152807
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