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Subfoveal choroidal thickness as a predictor of treatment response to anti-vascular endothelial growth factor therapy for polypoidal choroidal vasculopathy

DC FieldValueLanguage
dc.contributor.author고형준-
dc.contributor.author변석호-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author이지환-
dc.contributor.author권계윤-
dc.contributor.author김민-
dc.contributor.author김성수-
dc.contributor.author김혜선-
dc.date.accessioned2017-10-26T07:59:44Z-
dc.date.available2017-10-26T07:59:44Z-
dc.date.issued2016-
dc.identifier.issn0721-832X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152796-
dc.description.abstractPURPOSE: To investigate whether subfoveal choroidal thickness predicted treatment response to anti-vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective observational case series included 66 eyes of 60 patients who were diagnosed with new-onset PCV and who were followed for a minimum of 6 months. Patients received three monthly intravitreal injections of 0.5 mg ranibizumab or 1.25 mg bevacizumab, at baseline, month 1, and month 2. ""Good responders"" were defined as those who showed complete resolution of subretinal and/or intraretinal fluid at month 3 after the loading injections, whereas ""poor responders"" were defined as those who showed persistent retinal fluid on optical coherence tomography (OCT) at month 3 after treatment. Differences in best-corrected visual acuity, indocyanine green angiography, and spectral domain-OCT findings at baseline were analyzed between the two groups. RESULTS: The mean patient age was 68.2?±?9.7 years, and the mean follow-up period was 27?±?21 months. The mean subfoveal choroidal thickness was 273?±?117 μm, and choroidal vascular hyperpermeability was observed in 35 eyes (53.0 %). Thirty-three eyes (50 %) showed good response to treatment, and a thinner subfoveal choroid at baseline significantly correlated with favorable treatment response (P?=?0.024). However, there was no significant relationship between treatment response and choroidal vascular hyperpermeability (P?=?0.999). CONCLUSIONS: The subfoveal choroid was found to be significantly thinner among patients who achieved complete resolution of macular exudation after three loading injections of anti-VEGF agents.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish, German-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAngiogenesis Inhibitors/administration & dosage-
dc.subject.MESHBevacizumab/administration & dosage*-
dc.subject.MESHChoroid/blood supply*-
dc.subject.MESHChoroid/diagnostic imaging-
dc.subject.MESHChoroid Diseases/diagnosis-
dc.subject.MESHChoroid Diseases/drug therapy*-
dc.subject.MESHChoroid Diseases/physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHFluorescein Angiography-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHFundus Oculi-
dc.subject.MESHHumans-
dc.subject.MESHIntravitreal Injections-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRanibizumab/administration & dosage*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVascular Endothelial Growth Factor A/antagonists & inhibitors*-
dc.subject.MESHVisual Acuity-
dc.titleSubfoveal choroidal thickness as a predictor of treatment response to anti-vascular endothelial growth factor therapy for polypoidal choroidal vasculopathy-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorHyesun Kim-
dc.contributor.googleauthorSung Chul Lee-
dc.contributor.googleauthorKye Yoon Kwon-
dc.contributor.googleauthorJi Hwan Lee-
dc.contributor.googleauthorHyoung Jun Koh-
dc.contributor.googleauthorSuk Ho Byeon-
dc.contributor.googleauthorSung Soo Kim-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.identifier.doi10.1007/s00417-015-3221-x-
dc.contributor.localIdA00152-
dc.contributor.localIdA01849-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA03222-
dc.contributor.localIdA04715-
dc.contributor.localIdA00455-
dc.contributor.localIdA00571-
dc.contributor.localIdA01173-
dc.relation.journalcodeJ00951-
dc.identifier.eissn1435-702X-
dc.identifier.pmid26626772-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00417-015-3221-x-
dc.subject.keywordAnti-vascular endothelial growth factor-
dc.subject.keywordPolypoidal choroidal vasculopathy-
dc.subject.keywordSubfoveal choroidal thickness-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameByeon, Suk Ho-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.alternativeNameLee, Seung Kyu-
dc.contributor.alternativeNameLee, Ji Hwan-
dc.contributor.alternativeNameKwon, Kye Yoon-
dc.contributor.alternativeNameKim, Min-
dc.contributor.alternativeNameKim, Sung Soo-
dc.contributor.alternativeNameKim, Hye Sun-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorByeon, Suk Ho-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.contributor.affiliatedAuthorLee, Seung Kyu-
dc.contributor.affiliatedAuthorLee, Ji Hwan-
dc.contributor.affiliatedAuthorKwon, Kye Yoon-
dc.contributor.affiliatedAuthorKim, Min-
dc.contributor.affiliatedAuthorKim, Sung Soo-
dc.contributor.affiliatedAuthorKim, Hye Sun-
dc.citation.volume254-
dc.citation.number8-
dc.citation.startPage1497-
dc.citation.endPage1503-
dc.identifier.bibliographicCitationGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.254(8) : 1497-1503, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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