Cited 10 times in
Development of a novel dual PLGA and alginate coated drug-eluting stent for enhanced blood compatibility
DC Field | Value | Language |
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dc.contributor.author | 정복영 | - |
dc.date.accessioned | 2017-10-26T07:58:44Z | - |
dc.date.available | 2017-10-26T07:58:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152769 | - |
dc.description.abstract | In this study, a dual-coated stent with two types of synthetic and natural polymers was reported for enhanced blood compatibility with anti-proliferation and anti-coagulation activities. A cobalt-chromium metal stent was coated with sirolimus-loaded poly(lactic-co-glycolic acid) (PLGA) via ultrasonic spray method and the PLGA-coated stent was then covered with heparin-loaded alginate hydrogel to reduce in-stent restenosis and blood coagulation. Surface morphology and thickness of the double-layer coated stent was characterized using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). In vitro degradation profile of cross-linked alginate hydrogel was examined related to the effect of CaCl2 concentration. Platelet adhesion and fibrinogen adsorption studies indicated that such dual-coated stent had a good blood compatibility to be used as a vascular drug-eluting stent. In vitro drug release studies and rat vascular smooth muscle cells (RVSMC) proliferation assay showed the effective anti-proliferation activity of smooth muscle cells on the dual-coated drug-eluting stents. These excellent results suggest that dual-coated stent with sirolimus-loaded PLGA and heparin-loaded alginate hydrogel had a great potential for the development of blood compatibility with effective inhibition of initial thrombosis and stenosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Polymer Society of Korea | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Development of a novel dual PLGA and alginate coated drug-eluting stent for enhanced blood compatibility | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Advanced General Dentistry | - |
dc.contributor.googleauthor | Jung Ho Kim | - |
dc.contributor.googleauthor | Na Re Ko | - |
dc.contributor.googleauthor | Bock-Young Jung | - |
dc.contributor.googleauthor | Il Keun Kwon | - |
dc.identifier.doi | 10.1007/s13233-016-4130-5 | - |
dc.contributor.localId | A03610 | - |
dc.relation.journalcode | J02177 | - |
dc.identifier.eissn | 2092-7673 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s13233-016-4130-5 | - |
dc.subject.keyword | drun-eluting stet | - |
dc.subject.keyword | sirolimus | - |
dc.subject.keyword | heparin | - |
dc.subject.keyword | alginate scaffold | - |
dc.contributor.alternativeName | Jung, Bok Yeong | - |
dc.contributor.affiliatedAuthor | Jung, Bok Yeong | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 931 | - |
dc.citation.endPage | 939 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, Vol.24(10) : 931-939, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 39777 | - |
dc.type.rims | ART | - |
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