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Development of a novel dual PLGA and alginate coated drug-eluting stent for enhanced blood compatibility

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dc.contributor.author정복영-
dc.date.accessioned2017-10-26T07:58:44Z-
dc.date.available2017-10-26T07:58:44Z-
dc.date.issued2016-
dc.identifier.issn1598-5032-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152769-
dc.description.abstractIn this study, a dual-coated stent with two types of synthetic and natural polymers was reported for enhanced blood compatibility with anti-proliferation and anti-coagulation activities. A cobalt-chromium metal stent was coated with sirolimus-loaded poly(lactic-co-glycolic acid) (PLGA) via ultrasonic spray method and the PLGA-coated stent was then covered with heparin-loaded alginate hydrogel to reduce in-stent restenosis and blood coagulation. Surface morphology and thickness of the double-layer coated stent was characterized using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). In vitro degradation profile of cross-linked alginate hydrogel was examined related to the effect of CaCl2 concentration. Platelet adhesion and fibrinogen adsorption studies indicated that such dual-coated stent had a good blood compatibility to be used as a vascular drug-eluting stent. In vitro drug release studies and rat vascular smooth muscle cells (RVSMC) proliferation assay showed the effective anti-proliferation activity of smooth muscle cells on the dual-coated drug-eluting stents. These excellent results suggest that dual-coated stent with sirolimus-loaded PLGA and heparin-loaded alginate hydrogel had a great potential for the development of blood compatibility with effective inhibition of initial thrombosis and stenosis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherPolymer Society of Korea-
dc.relation.isPartOfMACROMOLECULAR RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDevelopment of a novel dual PLGA and alginate coated drug-eluting stent for enhanced blood compatibility-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Advanced General Dentistry-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorNa Re Ko-
dc.contributor.googleauthorBock-Young Jung-
dc.contributor.googleauthorIl Keun Kwon-
dc.identifier.doi10.1007/s13233-016-4130-5-
dc.contributor.localIdA03610-
dc.relation.journalcodeJ02177-
dc.identifier.eissn2092-7673-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s13233-016-4130-5-
dc.subject.keyworddrun-eluting stet-
dc.subject.keywordsirolimus-
dc.subject.keywordheparin-
dc.subject.keywordalginate scaffold-
dc.contributor.alternativeNameJung, Bok Yeong-
dc.contributor.affiliatedAuthorJung, Bok Yeong-
dc.citation.volume24-
dc.citation.number10-
dc.citation.startPage931-
dc.citation.endPage939-
dc.identifier.bibliographicCitationMACROMOLECULAR RESEARCH, Vol.24(10) : 931-939, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid39777-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers

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