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Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration
DC Field | Value | Language |
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dc.contributor.author | 정복영 | - |
dc.date.accessioned | 2017-10-26T07:58:40Z | - |
dc.date.available | 2017-10-26T07:58:40Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152765 | - |
dc.description.abstract | In this study, the effect of novel BMP-2-loaded photo-cured hydrogels on in vitro and in vivo osteogenesis were explored. The well-defined HA-heparin hydrogel was prepared by a photopolymerization of aminoethyl methacrylate (AEMA) grafted hyaluronic acid (HA) and AEMA-grafted heparin. Subsequently, the resulting hydrogels contained BMP-2 at different concentrations. First, a series of BMP-2-loaded hydrogels were characterized to determine their mechanical properties and release profiles. The results from rheology, swelling ratio, and release kinetics suggest that BMP-2 contained HA-g-Hhep gel (B/HA-g-Hhep gel) had sustained release during 4 weeks with minimal initial burst. Furthermore, the released BMP-2 maintained its biological activity. MTT and live/dead assays showed that the B/HA-g-Hhep gel had good biocompatibility to be used as a scaffold for bone regeneration. In vivo studies of B/HA-g-Hhep gel exhibited significantly enhanced osteogenesis, compared with other types of HA-heparin hydrogels. These excellent results indicated that B/HA-g-Hhep gel has a great potential for a controlled release of growth factor, leading to a good bone regeneration. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Polymer Society of Korea | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Advanced General Dentistry | - |
dc.contributor.googleauthor | Min Soo Bae | - |
dc.contributor.googleauthor | Na Re Ko | - |
dc.contributor.googleauthor | Sang Jin Lee | - |
dc.contributor.googleauthor | Jung Bok Lee | - |
dc.contributor.googleauthor | Dong Nyoung Heo | - |
dc.contributor.googleauthor | Wook Byun | - |
dc.contributor.googleauthor | Byung-Joon Choi | - |
dc.contributor.googleauthor | Hoon Bong Jeon | - |
dc.contributor.googleauthor | Hee-Jae Jang | - |
dc.contributor.googleauthor | Ji-Yoon Ahn | - |
dc.contributor.googleauthor | Deok-Sang Hwang | - |
dc.contributor.googleauthor | Bock-Young Jung | - |
dc.contributor.googleauthor | Il Keun Kwon | - |
dc.identifier.doi | 10.1007/s13233-016-4112-7 | - |
dc.contributor.localId | A03610 | - |
dc.relation.journalcode | J02177 | - |
dc.identifier.eissn | 2092-7673 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs13233-016-4112-7 | - |
dc.subject.keyword | photopolymerization | - |
dc.subject.keyword | hyaluronic acid | - |
dc.subject.keyword | heparin | - |
dc.subject.keyword | hydrogel | - |
dc.subject.keyword | growth factor | - |
dc.subject.keyword | bone tissue regeneration | - |
dc.contributor.alternativeName | Jung, Bok Yeong | - |
dc.contributor.affiliatedAuthor | Jung, Bok Yeong | - |
dc.citation.volume | 24 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 829 | - |
dc.citation.endPage | 837 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, Vol.24(9) : 829-837, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 39773 | - |
dc.type.rims | ART | - |
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