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IgE cross-reactivity of peanut with walnut and soybean in children with food allergy

Authors
 M.N. Kim  ;  K.E. Lee  ;  J.Y. Hong  ;  K.W. Kim  ;  K.-E. Kim  ;  M.H. Sohn  ;  J.W. Park 
Citation
 Allergologia et Immunopathologia, Vol.44(6) : 524-530, 2016 
Journal Title
 Allergologia et Immunopathologia 
ISSN
 0301-0546 
Issue Date
2016
Abstract
BACKGROUND: Peanut allergies are common and can be life-threating for sensitised individuals. Peanut allergens share significant amino acid homology with those of other legumes and tree nuts, but their cross-reactivity still remains unclear. OBJECTIVE: We sought to determine the clinical significance of the cross-reactivity of peanut allergens with those of walnut and soybean. METHODS: Pooled sera from eight subjects with both peanut and walnut specific IgE were investigated in an inhibition test. After the sera were incubated with either peanut or walnut protein extracts, the quantity of IgE antibodies against the peanut and walnut was measured using an immunoCAP test. Likewise, pooled sera from 18 subjects with both peanut and soybean specific IgE antibodies were incubated with either peanut or soybean protein extracts and evaluated with a peanut and soybean immunoCAP test. SDS-PAGE and immunoblotting were also performed with peanut, walnut and soybean protein extracts and relevant sera. RESULTS: Peanut specific IgE was inhibited up to 20% and 26% by walnut and soybean protein extracts, respectively. In reverse, walnut and soybean specific IgE were inhibited up to 21% and 23% by peanut protein extracts, respectively. In the immunoblot analysis, pooled serum from the subjects with peanut specific IgE antibodies reacted with walnut protein extracts significantly. CONCLUSION: Although the clinical significance of the cross-reactivity of peanut specific IgE with walnut and soybean protein extracts has not been established, we believe that individuals who are allergic to peanuts need to be cautious about consuming walnuts and soybeans.
Full Text
http://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-resumen-ige-cross-reactivity-peanut-with-walnut-S030105461630074X
DOI
10.1016/j.aller.2016.04.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152735
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