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A New Efficient Method for Detecting Phase Singularity in Cardiac Fibrillation

 Young-Seon Lee  ;  Jun-Seop Song  ;  Minki Hwang  ;  Byounghyun Lim  ;  Boyoung Joung  ;  Hui-Nam Pak 
 PLoS One, Vol.11(12) : e0167567, 2016 
Journal Title
 PLoS One 
Issue Date
BACKGROUND: The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. METHODS: In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2π (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs. We tested the efficiency and robustness of these two methods in a two-dimensional mathematical model of atrial fibrillation (AF), with and without remodeling of ionic currents. RESULTS: 1. There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the PS points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods. 2. For the condition of electrical remodeling of AF (0.3 × ICaL), the PS points calculated by the two methods were satisfactorily co-localized (with the Hausdorff distance of 1.64 ± 0.09 mm). 3. The proposed location-centric method was substantially more efficient than the Iyer-Gray method, with a 28.6-fold and 28.2-fold shorter run times for the control and remodeling scenarios, respectively. CONCLUSION: We propose a new location-centric method for calculating PS, which is robust and more efficient compared with the conventionally used method.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
박희남(Pak, Hui Nam) ORCID logo https://orcid.org/0000-0002-3256-3620
임병현(Lim, Byounghyun)
정보영(Joung, Bo Young) ORCID logo https://orcid.org/0000-0001-9036-7225
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