Cited 5 times in
Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2017-10-26T07:56:14Z | - |
dc.date.available | 2017-10-26T07:56:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152711 | - |
dc.description.abstract | BACKGROUND: Little information is available regarding vitamin D-associated factors in patients with non-tuberculous mycobacteria (NTM) lung disease. OBJECTIVE: To determine the association between vitamin D-related factors and susceptibility to NTM lung disease. DESIGN: The relative gene expression levels of cathelicidin (CAMP), defensin (DEFB4), vitamin D receptor (VDR) and 1-hydroxylase (CYP27B1), as well as the serum levels of 25-hydroxyvitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and vitamin D-binding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed. RESULTS: Gene expression of CAMP and DEFB4 was significantly higher, and gene expression of VDR and CYP27B1 was significantly lower, in NTM patients than controls. Serum LL-37 and hBD-2 levels were not significantly different between NTM patients and controls; however, the serum DBP level was higher in NTM patients than controls. The serum vitamin D status of patients did not correlate with serum LL-37, hBD-2, or DBP concentration or gene expression of CAMP, DEFB4, VDR or CYP27B1. CONCLUSION: A higher level of gene expression for antimicrobial peptide is more likely to be associated with NTM lung disease than serum vitamin D status. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | The Union | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease | - |
dc.type | Article | - |
dc.publisher.location | France | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | S-Y. Kim | - |
dc.contributor.googleauthor | B. Chang | - |
dc.contributor.googleauthor | B-H. Jeong | - |
dc.contributor.googleauthor | H. Y. Park | - |
dc.contributor.googleauthor | K. Jeon | - |
dc.contributor.googleauthor | S. J. Shin | - |
dc.contributor.googleauthor | W-J. Koh | - |
dc.identifier.doi | 10.5588/ijtld.16.0347 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01167 | - |
dc.identifier.eissn | 1815-7920 | - |
dc.identifier.pmid | 27931333 | - |
dc.identifier.url | https://www.ingentaconnect.com/content/iuatld/ijtld/2016/00000020/00000012/art00007 | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 20 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1594 | - |
dc.citation.endPage | 1602 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.20(12) : 1594-1602, 2016 | - |
dc.date.modified | 2017-10-24 | - |
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