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Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry

DC Field Value Language
dc.contributor.author정한성-
dc.date.accessioned2017-10-26T07:54:51Z-
dc.date.available2017-10-26T07:54:51Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152684-
dc.description.abstractThe anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial invagination. Despite the well-defined roles of EK in cusp patterning, the determinants of the ultimate cuspal shapes and involvement of epithelial cellular geometry are unknown. Using two typical tooth patterns, the lophodont in gerbils and the bunodont in mice, we showed that the cuspal shape is determined by the dental epithelium at the cap stage, whereas the cellular geometry in the inner dental epithelium (IDE) is correlated with the cuspal shape. Intriguingly, fine tuning Rac1 and RhoA interconvert cuspal shapes between two species by remolding the cellular geometry. Either inhibition of Rac1 or ectopic expression of RhoA could region-distinctively change the columnar shape of IDE cells in gerbils to drive invagination to produce cusps. Conversely, RhoA reduction in mice inhibited invagination and developed lophs. Furthermore, we found that Rac1 and RhoA modulate the choices of cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin localization to drive IDE invagination.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/octet-stream-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorLiwen Li-
dc.contributor.googleauthorQinghuang Tang-
dc.contributor.googleauthorTakashi Nakamura-
dc.contributor.googleauthorJun-Gyo Suh-
dc.contributor.googleauthorHayato Ohshima-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1038/srep37828-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid27892530-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.citation.volume6-
dc.citation.startPage37828-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.6 : 37828, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid39693-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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