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Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases

Authors
 Hwa Jeong You  ;  Jae Hyon Park  ;  Helios Pareja-Galeano  ;  Alejandro Lucia  ;  Jae Il Shin 
Citation
 NEUROMOLECULAR MEDICINE, Vol.18(4) : 540-550, 2016 
Journal Title
NEUROMOLECULAR MEDICINE
ISSN
 1535-1084 
Issue Date
2016
Abstract
Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges.
Full Text
https://link.springer.com/article/10.1007%2Fs12017-016-8407-9
DOI
10.1007/s12017-016-8407-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152664
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