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A Microfluidics-based Pulpal Arteriole Blood Flow Phantom for Validation of Doppler Ultrasound Devices in Pulpal Blood Flow Velocity Measurement

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dc.contributor.author김도현-
dc.contributor.author박성호-
dc.date.accessioned2017-10-26T07:50:39Z-
dc.date.available2017-10-26T07:50:39Z-
dc.date.issued2016-
dc.identifier.issn0099-2399-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152583-
dc.description.abstractINTRODUCTION: Recently, Doppler ultrasound has been used for the measurement of pulpal blood flow in human teeth. However, the reliability of this method has not been verified. In this study, we developed a model to simulate arteriole blood flow within the dental pulp by using microfluidics. This arteriole simulator, or flow phantom, was used to determine the reliability of measurements obtained by using a Doppler ultrasound device. METHODS: A microfluidic chip was fabricated by using the soft lithography technique, and blood-mimicking fluid was pumped through the channel by a microfluidic system. A Doppler ultrasound device was used for the measurement of flow velocity. The peak, mean, and minimal flow velocities obtained from the phantom and the Doppler ultrasound device were compared by using linear regression analysis and Pearson correlation coefficient. Bland-Altman analyses were performed to evaluate the velocity differences between the flow generated by the phantom and the flow measurements made with the Doppler ultrasound device. RESULTS: The microfluidic system was able to generate the flow profiles as intended, and the fluid flow could be monitored and controlled by the software program. There were excellent linear correlations between the peak, mean, and minimal flow velocities of the phantom and those of the Doppler ultrasound device (r = 0.94-0.996, P < .001). However, the velocities were overestimated by the Doppler ultrasound device. CONCLUSIONS: This phantom provides opportunities for research and education involving the Doppler ultrasound technique in dentistry. Although Doppler ultrasound can be an effective tool for the measurement of pulpal blood flow velocity, it is essential to validate and calibrate the device before clinical use.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF ENDODONTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHArterioles/physiology-
dc.subject.MESHBlood Flow Velocity-
dc.subject.MESHDental Pulp/blood supply*-
dc.subject.MESHHumans-
dc.subject.MESHMicrofluidics/instrumentation*-
dc.subject.MESHMicrofluidics/methods-
dc.subject.MESHPhantoms, Imaging-
dc.subject.MESHPulsatile Flow-
dc.subject.MESHRegional Blood Flow-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHUltrasonography, Doppler/instrumentation*-
dc.subject.MESHUltrasonography, Doppler/methods-
dc.titleA Microfluidics-based Pulpal Arteriole Blood Flow Phantom for Validation of Doppler Ultrasound Devices in Pulpal Blood Flow Velocity Measurement-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Conservative Dentistry-
dc.contributor.googleauthorDohyun Kim-
dc.contributor.googleauthorSung-Ho Park-
dc.identifier.doi10.1016/j.joen.2016.08.008-
dc.contributor.localIdA01514-
dc.contributor.localIdA00389-
dc.relation.journalcodeJ01393-
dc.identifier.eissn1878-3554-
dc.identifier.pmid27651041-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0099239916305234?via%3Dihub-
dc.subject.keywordDoppler ultrasound-
dc.subject.keywordflow phantom-
dc.subject.keywordmicrofluidic chip-
dc.subject.keywordmicrofluidics-
dc.subject.keywordpulpal blood flow velocity-
dc.contributor.alternativeNameKim, Dohyun-
dc.contributor.alternativeNamePark, Sung Ho-
dc.contributor.affiliatedAuthorPark, Sung Ho-
dc.contributor.affiliatedAuthorKim, Dohyun-
dc.citation.volume42-
dc.citation.number11-
dc.citation.startPage1660-
dc.citation.endPage1666-
dc.identifier.bibliographicCitationJOURNAL OF ENDODONTICS, Vol.42(11) : 1660-1666, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48784-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers

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