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Finite Element Analysis of the Effect of Epidural Adhesions

Authors
 Nam Lee  ;  Gyu Yeul Ji  ;  Seong Yi  ;  Do Heum Yoon  ;  Dong Ah Shin  ;  Keung Nyun Kim  ;  Yoon Ha  ;  Chang Hyun Oh 
Citation
 Pain Physician, Vol.19(5) : 787-793, 2016 
Journal Title
 Pain Physician 
ISSN
 1533-3159 
Issue Date
2016
MeSH
Back Pain/etiology* ; Dura Mater/pathology* ; Epidural Space/pathology ; Finite Element Analysis* ; Humans ; Tissue Adhesions/complications*
Keywords
Finite element ; epidural adhesion ; spinal pain ; adhesiolysis
Abstract
BACKGROUND: It is well documented that epidural adhesion is associated with spinal pain. However, the underlying mechanism of spinal pain generation by epidural adhesion has not yet been elucidated. OBJECTIVES: To elucidate the underlying mechanism of spinal pain generation by epidural adhesion using a two-dimensional (2D) non-linear finite element (FE) analysis. STUDY DESIGN: A finite element analysis. SETTING: A two-dimensional nonlinear FE model of the herniated lumbar disc on L4/5 with epidural adhesion. METHODS: A two-dimensional nonlinear FE model of the lumbar spine was developed, consisting of intervertebral discs, dura, spinal nerve, and lamina. The annulus fibrosus and nucleus pulpous were modeled as hyperelastic using the Mooney-Rivlin equation. The FE mesh was generated and analyzed using Abaqus (ABAQUS 6.13.; Hibbitt, Karlsson & Sorenson, Inc., Providence, RI, USA). Epidural adhesion was simulated as rough contact, in which no slip occurred once two surfaces were in contact, between the dura mater and posterior annulus fibrosus. RESULTS: The FE model of adhesion showed significant stress concentration in the spinal nerves, especially on the dorsal root ganglion (DRG). The stress concentration was caused by the lack of adaptive displacement between the dura mater and posterior annulus fibrosus. The peak von Mises stress was higher in the epidural adhesion model (Adhesion, 0.67 vs. Control, 0.46). In the control model, adaptive displacement was observed with decreased stress in the spinal nerve and DRG (with adhesion, 2.59 vs. without adhesion, 3.58, P < 0.00). LIMITATIONS: This study used a 2D non-linear FE model, which simplifies the 3D nature of the human intervertebral disc. In addition, this 2D non-linear FE model has not yet been validated. CONCLUSION: The current study clearly demonstrated that epidural adhesion causes significantly increased stress in the spinal nerves, especially at the DRG. We believe that the increased stress on the spinal nerve might elicit more pain under similar magnitudes of lumbar disc protrusion.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
김긍년(Kim, Keung Nyun)
신동아(Shin, Dong Ah) ORCID logo https://orcid.org/0000-0002-5225-4083
윤도흠(Yoon, Do Heum) ORCID logo https://orcid.org/0000-0003-1452-5724
이남(Lee, Nam)
이성(Yi, Seong)
하윤(Ha, Yoon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152574
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