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Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

DC Field Value Language
dc.contributor.author이중석-
dc.contributor.author조규성-
dc.contributor.author차재국-
dc.contributor.author최성호-
dc.date.accessioned2017-10-26T07:49:58Z-
dc.date.available2017-10-26T07:49:58Z-
dc.date.issued2016-
dc.identifier.issn2093-2278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152564-
dc.description.abstractPURPOSE: The purpose of the present study was to evaluate the effectiveness of a minimal concentration of bone morphogenetic protein-2 (BMP-2) in terms of quantitative and qualitative analyses of newly formed bone in a rabbit maxillary sinus model. METHODS: In 7 rabbits, sinus windows were prepared bilaterally. Biphasic calcium phosphate (BCP) loaded with 0.05 mg/mL BMP-2 was grafted into one sinus (the BMP group) and saline-soaked BCP was placed into the other (the control group) in each animal. The animals were allowed an 8-week healing period before being sacrificed. Specimens including the augmented area and surrounding tissues were then removed and evaluated both radiographically and histologically. RESULTS: There was a difference in the mineralization of new bone between the groups. In the BMP group, the greater part of the new bone consisted of mature lamellar bone with an evident trabecular pattern, whereas the control group showed mostly woven bone, consisting only partially of lamellar bone. Histometrically, the area of new bone was significantly greater (4.55±1.35 mm2 vs. 2.99±0.86 mm2) in the BMP group than in the control group (P<0.05); however, the total augmentation volumes were not significantly different between the groups. CONCLUSIONS: Within the limitations of this study, it can be suggested that a minimal concentration of BMP-2 (0.05 mg/mL) had an osteoinductive effect with accelerated mineralization in a rabbit sinus model using a BCP carrier.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Academy of Periodontology-
dc.relation.isPartOfJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIncreased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Periodontology-
dc.contributor.googleauthorJae-Shin Kim-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorJung-Seok Lee-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.googleauthorKyoo-Sung Cho-
dc.identifier.doi10.5051/jpis.2016.46.5.350-
dc.contributor.localIdA03810-
dc.contributor.localIdA04004-
dc.contributor.localIdA04081-
dc.contributor.localIdA03185-
dc.relation.journalcodeJ01695-
dc.identifier.eissn2093-2286-
dc.relation.journalsince2010~-
dc.identifier.pmid27800217-
dc.relation.journalbefore~2009 Journal of Korean Academy of Periodontology (대한치주과학회지)-
dc.subject.keywordBone morphogenetic proteins-
dc.subject.keywordHydroxyapatite-beta tricalcium phosphate-
dc.subject.keywordPhysiologic calcification-
dc.subject.keywordSinus floor augmentation-
dc.contributor.alternativeNameLee, Jung Seok-
dc.contributor.alternativeNameCho, Kyoo Sung-
dc.contributor.alternativeNameCha, Jae Kook-
dc.contributor.alternativeNameChoi, Seong Ho-
dc.contributor.affiliatedAuthorCho, Kyoo Sung-
dc.contributor.affiliatedAuthorCha, Jae Kook-
dc.contributor.affiliatedAuthorChoi, Seong Ho-
dc.contributor.affiliatedAuthorLee, Jung Seok-
dc.citation.volume46-
dc.citation.number5-
dc.citation.startPage350-
dc.citation.endPage359-
dc.identifier.bibliographicCitationJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.46(5) : 350-359, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48766-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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