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Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer

 Cheal Wung Huh  ;  Da Hyun Jung  ;  Hyunki Kim  ;  Hoguen Kim  ;  Young Hoon Youn  ;  Hyojin Park  ;  Jong Won Kim  ;  Seung Ho Choi  ;  Sung Hoon Noh  ;  Jie-Hyun Kim 
 JOURNAL OF SURGICAL ONCOLOGY, Vol.114(6) : 769-772, 2016 
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Issue Date
Adult ; Aged ; Case-Control Studies ; Early Detection of Cancer ; Female ; Gastrectomy ; Gastric Mucosa/pathology* ; Humans ; Lymphatic Metastasis ; Lymphoid Tissue/pathology* ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Retrospective Studies ; Stomach Neoplasms/diagnosis* ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Analysis
early gastric cancer ; gastric carcinoma with lymphoid stroma ; lymph node metastasis
BACKGROUND AND OBJECTIVES: Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC). METHODS: Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM). RESULTS: Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the GCLS group showed a greater predominance among males, greater tendency towards proximal location, a more elevated gross appearance, and deeper submucosal invasion. In particular, more than 90% of GCLS cases showed deep submucosal invasion. The LNM rate was significantly lower in GCLS than non-GCLS cases after adjustment for depth of invasion. Among the GCLS group, there was no LNM in the cases with lesions confined to the mucosa or submucosal invasive lesions with tumor size ≤10?mm. CONCLUSIONS: In EGC, GCLS showed deeper submucosal invasion and a lower LNM rate compared with non-GCLS. Thus, clinical considerations of GCLS may be helpful to decide on a specific cancer treatment.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Kim, Hogeun(김호근)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Jung, Da Hyun(정다현) ORCID logo https://orcid.org/0000-0001-6668-3113
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
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