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Correlation of Early Recurrence With In Vitro Adenosine Triphosphate Based Chemotherapy Response Assay in Pancreas Cancer With Postoperative Gemcitabine Chemotherapy

Authors
 Joon Seong Park,  ;  Jae Keun Kim  ;  Dong Sup Yoon 
Citation
 JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.30(6) : 804-810, 2016 
Journal Title
JOURNAL OF CLINICAL LABORATORY ANALYSIS
ISSN
 0887-8013 
Issue Date
2016
MeSH
Adenosine Triphosphate/metabolism* ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Deoxycytidine/analogs & derivatives* ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Disease-Free Survival ; Drug Screening Assays, Antitumor* ; Female ; Humans ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use* ; Longitudinal Studies ; Male ; Middle Aged ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy* ; Pancreaticoduodenectomy/methods ; Predictive Value of Tests ; Republic of Korea ; Retrospective Studies ; Tumor Cells, Cultured
Keywords
chemoresistance ; in vitro adenosine triphosphate based chemotherapy response assay ; pancreas cancer ; postoperative adjuvant chemotherapy ; recurrence
Abstract
INTRODUCTION: Gemcitabine-based regimens represent the standard systemic first line treatment in patients after pancreatic resection. However, the clinical impact of gemcitabine varies significantly in individuals because of chemoresistance. An in vitro adenosine triphosphate based chemotherapy response assay (ATP-CRA) was designed to evaluate the sensitivity of cancer cells to various chemotherapeutic agents. This study investigated the correlation between in vitro gemcitabine sensitivity of tumor cells and early recurrence after curative resection.

METHOD: From January 2007 to December 2010, the ATP-CRA for gemcitabine was tested in 64 patients surgically treated for pancreas cancer at Gangnam Severance Hospital, Seoul, Korea. We analyzed the relationship between chemosensitivity and early systemic recurrence in patients with pancreas cancer to predict disease-free survival (DFS) after curative resection in pancreas cancer.

RESULT: The mean cell death rate (CDR) was 20.0 (±14.5) and divided into two groups according to the mean values of the CDR. Lymphovascular invasion was more frequently shown in gemcitabine resistance group without statistical significance. In univariate and multivariate analysis, advanced tumor stage and gemcitabine sensitive group (CDR ≥ 20) were identified as independent prognostic factors for DFS.

CONCLUSIONS: Gemcitabine sensitivity measured by ATP-CRA was well correlated with in vivo drug responsibility to predict early recurrence following gemcitabine-based adjuvant chemotherapy in patients with pancreas cancer.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jcla.21940/abstract
DOI
10.1002/jcla.21940
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Keun(김재근)
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152522
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