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Carotid Intima-Media Thickness is Inversely Related to Bone Density in Female but not in Male Patients with Acute Stroke

Authors
 Shi Nae Kim  ;  Hye Sun Lee  ;  Hyo Suk Nam  ;  Hwa Reung Lee  ;  Jung Min Kim  ;  Sang Won Han  ;  Joong Hyun Park  ;  Jong Sam Baik  ;  Jeong Yeon Kim  ;  Jae Hyeon Park 
Citation
 JOURNAL OF NEUROIMAGING, Vol.26(1) : 83-88, 2016 
Journal Title
JOURNAL OF NEUROIMAGING
ISSN
 1051-2284 
Issue Date
2016
MeSH
Aged ; Aged, 80 and over ; Atherosclerosis/complications* ; Atherosclerosis/diagnostic imaging ; Bone Density/physiology* ; Brain Ischemia/complications* ; Brain Ischemia/diagnostic imaging ; Carotid Artery Diseases/complications* ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery, Internal/diagnostic imaging ; Carotid Intima-Media Thickness* ; Female ; Humans ; Male ; Middle Aged ; Osteoporosis/complications* ; Osteoporosis/diagnostic imaging ; Risk Factors ; Sex Factors ; Stroke/complications* ; Stroke/diagnostic imaging ; Ultrasonography/methods
Keywords
Atherosclerosis ; bone mineral density (BMD) ; intima-media thickness (IMT) ; stroke
Abstract
BACKGROUND AND PURPOSE: Atherosclerosis and osteoporosis are two major public health problems. It is still uncertain whether an abnormal carotid ultrasonography, either increased intima-media thickness (IMT) or plaque thickness, is associated with osteoporosis in acute ischemic stroke patients. To investigate the possible relationships between osteoporosis and carotid atherosclerosis, we evaluated the correlation between carotid IMT/plaque thickness and bone mineral density (BMD) in acute ischemic stroke patients. METHODS: Patients having their first ischemic stroke within seven days were screened for the study. The IMT was scanned approximately 10 mm proximal to the beginning of the dilatation of the carotid bulb. The plaques were measured in both common and internal carotid arteries. The BMD was measured at total hip and lumbar spine in the anterior-posterior projection, using dual-energy x-ray absorptiometry. RESULTS: A total of 155 patients were enrolled in the study and the mean age was 68.3 ± 10.34 years. Multiple linear regression analysis reveals that age (P < .001), smoking (P = .016), and osteoporosis (P = .001) were significantly associated with increased carotid IMT/plaque thickness. Old age, current smoking, and osteoporosis were significantly related to increased IMT/plaque thickness in acute ischemic stroke patients. In women, IMT/plaque thickness was significantly related to age (P = .01) and osteoporosis (P = .025). In men, though there was no significant relationship, a trend toward old age and having osteoporosis was observed in increased IMT/plaque thickness (P = .051, P = .086). CONCLUSIONS: This study showed that carotid IMT/plaque thickness was inversely related to the BMD in female but not in male patients with acute ischemic stroke.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jon.12284/abstract
DOI
10.1111/jon.12284
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152502
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