Cited 30 times in
Benefit of Adjuvant Chemotherapy After Curative Resection of Lung Metastasis in Colorectal Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대준 | - |
dc.contributor.author | 박형순 | - |
dc.contributor.author | 범승훈 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 이민구 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2017-10-26T07:46:15Z | - |
dc.date.available | 2017-10-26T07:46:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152496 | - |
dc.description.abstract | BACKGROUND: The survival benefit of adjuvant chemotherapy after colorectal cancer (CRC) lung metastasectomy is uncertain. METHODS: We enrolled 221 CRC patients who underwent pulmonary metastasectomy between October 2002 and July 2013, including those with previous liver metastasis that had been curatively resected. Disease-free survival (DFS) and overall survival (OS) were calculated from the day of lung metastasectomy. RESULTS: Among all patients, 176 (79.6%) received adjuvant chemotherapy after lung metastasectomy. Median follow-up was 34.7 months from the time of lung metastasectomy [95% confidence interval (95% CI), 7.4-90.9 months]. Patients treated with adjuvant chemotherapy had longer DFS compared with surgery alone (median 32.7 vs 11.2 months respectively, P = 0.076). Multivariate analysis revealed previous liver metastasis, preoperative carcinoembryonic antigen ≥5 ng/mL, disease-free interval <24 months, and surgery without adjuvant chemotherapy as independent risk factors for recurrence. Low-risk patients who had 0-1 risk factors received a significant survival benefit from adjuvant chemotherapy [hazard ratio (HR) 0.54; 95% CI 0.32-0.91, P = 0.020]; however, high-risk patients with ≥2 risk factors did not (HR 1.02; 95% CI 0.48-2.14, P = 0.964). Patients treated with adjuvant chemotherapy showed no OS benefit compared with patients who received surgery alone (median 89.6 vs 86.8 months respectively, P = 0.833). CONCLUSIONS: CRC patients received lung metastasectomy could have a DFS benefit from adjuvant chemotherapy, especially in low-risk patients. Larger, prospective studies are needed to evaluate the role of adjuvant chemotherapy after CRC lung metastasectomy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/drug therapy* | - |
dc.subject.MESH | Adenocarcinoma/secondary | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Colorectal Neoplasms/drug therapy* | - |
dc.subject.MESH | Colorectal Neoplasms/pathology | - |
dc.subject.MESH | Colorectal Neoplasms/surgery | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/drug therapy* | - |
dc.subject.MESH | Lung Neoplasms/secondary | - |
dc.subject.MESH | Lung Neoplasms/surgery | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metastasectomy* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/drug therapy* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Neoplasm Recurrence, Local/surgery | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Pneumonectomy | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Benefit of Adjuvant Chemotherapy After Curative Resection of Lung Metastasis in Colorectal Cancer | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery | - |
dc.contributor.googleauthor | Hyung Soon Park | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Su Jin Heo | - |
dc.contributor.googleauthor | Chang Gon Kim | - |
dc.contributor.googleauthor | Min Goo Lee | - |
dc.contributor.googleauthor | Seung Hoon Beom | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.identifier.doi | 10.1245/s10434-015-4951-z | - |
dc.contributor.localId | A04576 | - |
dc.contributor.localId | A04581 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A02781 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A04355 | - |
dc.contributor.localId | A00368 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 26514121 | - |
dc.identifier.url | https://link.springer.com/article/10.1245%2Fs10434-015-4951-z | - |
dc.subject.keyword | Overall Survival | - |
dc.subject.keyword | Liver Metastasis | - |
dc.subject.keyword | Adjuvant Chemotherapy | - |
dc.subject.keyword | Lung Metastasis | - |
dc.subject.keyword | National Comprehensive Cancer Network | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Park, Hyung Soon | - |
dc.contributor.alternativeName | Beum, Seung Hoon | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Lee, Min Goo | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.alternativeName | Heo, Su Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyung Soon | - |
dc.contributor.affiliatedAuthor | Beum, Seung Hoon | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Lee, Min Goo | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Heo, Su Jin | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 928 | - |
dc.citation.endPage | 935 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.23(3) : 928-935, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48699 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.