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Pilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution

DC FieldValueLanguage
dc.contributor.author김상우-
dc.contributor.author김혜련-
dc.contributor.author박형순-
dc.contributor.author이민구-
dc.date.accessioned2017-10-26T07:45:34Z-
dc.date.available2017-10-26T07:45:34Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152480-
dc.description.abstractWe evaluated the preliminary efficacy and feasibility of a next-generation sequencing (NGS)-based targeted anticancer therapy in refractory solid tumors at a Korean institution. Thirty-six patients with advanced cancer underwent molecular profiling with NGS with the intent of clinical application of available matched targeted agents. Formalin-fixed paraffin-embedded (FFPE) tumors were sequenced using the Comprehensive Cancer Panel (CCP) or FoundationOne in the Clinical Laboratory Improvement Amendments-certified laboratory in the USA. Response evaluations were performed according to RECIST v1.1. Four specimens did not pass the DNA quality test and 32 specimens were successfully sequenced with CCP (n = 31) and FoundationOne (n = 1). Of the 32 sequenced patients, 10 (31.3%) were ≤40 years. Twelve patients (37.5%) had received ≥3 types of prior systemic therapies. Of 24 patients with actionable mutations, five were given genotype-matched drugs corresponding to actionable mutations: everolimus to PIK3CA mutation in parotid carcinosarcoma (partial response) and tracheal squamous cell carcinoma (stable disease; 21% reduction), sorafenib to PDGFRA mutation in auditory canal adenocarcinoma (partial response), sorafenib to BRAF mutation in microcytic adnexal carcinoma (progressive disease), and afatinib to ERBB2 mutation in esophageal adenocarcinoma (progressive disease). Nineteen of 24 patients with actionable mutations could not undergo targeted therapy based on genomic testing because of declining performance status (10/24, 41.7%), stable disease with previous treatment (5/24, 20.8%), and lack of access to targeted medication (4/24, 16.7%). NGS-based targeted therapy may be a good option in selected patients with refractory solid tumors. To pursue this strategy in Korea, lack of access to clinical-grade NGS assays and a limited number of genotype-matched targeted medications needs to be addressed and resolved.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents/therapeutic use*-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHClass I Phosphatidylinositol 3-Kinases-
dc.subject.MESHDrug Resistance, Neoplasm/drug effects-
dc.subject.MESHDrug Resistance, Neoplasm/genetics-
dc.subject.MESHEverolimus/therapeutic use-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Predisposition to Disease/genetics-
dc.subject.MESHHigh-Throughput Nucleotide Sequencing/methods*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Targeted Therapy/methods*-
dc.subject.MESHMutation-
dc.subject.MESHNeoplasms/drug therapy*-
dc.subject.MESHNeoplasms/ethnology-
dc.subject.MESHNeoplasms/genetics-
dc.subject.MESHNiacinamide/analogs & derivatives-
dc.subject.MESHNiacinamide/therapeutic use-
dc.subject.MESHPhenylurea Compounds/therapeutic use-
dc.subject.MESHPhosphatidylinositol 3-Kinases/genetics-
dc.subject.MESHPilot Projects-
dc.subject.MESHPrecision Medicine/methods-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics-
dc.subject.MESHQuinazolines/therapeutic use-
dc.subject.MESHReceptor, Platelet-Derived Growth Factor alpha/genetics-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHYoung Adult-
dc.titlePilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorHyung Soon Park-
dc.contributor.googleauthorSun Min Lim-
dc.contributor.googleauthorSora Kim-
dc.contributor.googleauthorSangwoo Kim-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorKyuBum Kwack-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorJoo-Hang Kim-
dc.contributor.googleauthorYong Wha Moon-
dc.identifier.doi10.1371/journal.pone.0154133-
dc.contributor.localIdA01166-
dc.contributor.localIdA04576-
dc.contributor.localIdA02781-
dc.contributor.localIdA00524-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27105424-
dc.contributor.alternativeNameKim, Sang Woo-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNamePark, Hyung Soon-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorPark, Hyung Soon-
dc.contributor.affiliatedAuthorLee, Min Goo-
dc.contributor.affiliatedAuthorKim, Sang Woo-
dc.citation.volume11-
dc.citation.number4-
dc.citation.startPagee0154133-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(4) : e0154133, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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