0 75

Cited 1 times in

Atrophy of the pedunculopontine nucleus region in patients with sleep-predominant seizures: A voxel-based morphometry study

Authors
 Kyoo Ho Cho  ;  Yang-Je Cho  ;  Byung In Lee  ;  Kyoung Heo 
Citation
 Epilepsia, Vol.57(8) : 151-154, 2016 
Journal Title
 Epilepsia 
ISSN
 0013-9580 
Issue Date
2016
MeSH
Adolescent ; Adult ; Atrophy/etiology ; Female ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pedunculopontine Tegmental Nucleus/diagnostic imaging ; Pedunculopontine Tegmental Nucleus/pathology* ; Seizures/diagnostic imaging ; Seizures/pathology* ; Seizures/physiopathology* ; Sleep Stages/physiology* ; Young Adult
Keywords
Epilepsy ; Pedunculopontine nucleus ; Sleep ; Volumetry
Abstract
Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predominant seizures (SPS) show volume changes in the region of the PPN compared to those with seizures occurring during awake state only (nSPS). The volume of the PPN region was assessed in patients with SPS, those with nSPS, and healthy volunteers, through voxel-based morphometry and automated, nonbiased region of interest (ROI) analysis of T1 magnetic resonance (MR) images. The volume of PPN region was statistically smaller in patients with SPS (n = 33) than in those with nSPS (n = 40) and healthy controls (n = 30) after controlling for covariates. These results suggest that a structural change in the PPN may be associated with sleep-predominant timing of seizure occurrence. Our findings might help understand the intervening pathomechanism that lies between the human sleep-wake cycle and epilepsy.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/epi.13431/abstract
DOI
10.1111/epi.13431
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
Cho, Yang Je(조양제)
Heo, Kyoung(허경)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152467
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse