Cited 3 times in
Protocol-Based Resuscitation for Septic Shock: A Meta-Analysis of Randomized Trials and Observational Studies
DC Field | Value | Language |
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dc.contributor.author | 김정민 | - |
dc.contributor.author | 김하연 | - |
dc.contributor.author | 나성원 | - |
dc.contributor.author | 이우경 | - |
dc.contributor.author | 이진애 | - |
dc.date.accessioned | 2017-10-26T07:44:19Z | - |
dc.date.available | 2017-10-26T07:44:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152451 | - |
dc.description.abstract | PURPOSE: Owing to the recommendations of the Surviving Sepsis Campaign guidelines, protocol-based resuscitation or goal-directed therapy (GDT) is broadly advocated for the treatment of septic shock. However, the most recently published trials showed no survival benefit from protocol-based resuscitation in septic shock patients. Hence, we aimed to assess the effect of GDT on clinical outcomes in such patients. MATERIALS AND METHODS: We performed a systematic review that included a meta-analysis. We used electronic search engines including PubMed, Embase, and the Cochrane database to find studies comparing protocol-based GDT to common or standard care in patients with septic shock and severe sepsis. RESULTS: A total of 13269 septic shock patients in 24 studies were included [12 randomized controlled trials (RCTs) and 12 observational studies]. The overall mortality odds ratio (OR) [95% confidence interval (CI)] for GDT versus conventional care was 0.746 (0.631-0.883). In RCTs only, the mortality OR (95% CI) for GDT versus conventional care in the meta-analysis was 0.93 (0.75-1.16). The beneficial effect of GDT decreased as more recent studies were added in an alternative, cumulative meta-analysis. No significant publication bias was found. CONCLUSION: The result of this meta-analysis suggests that GDT reduces mortality in patients with severe sepsis or septic shock. However, our cumulative meta-analysis revealed that the reduction of mortality risk was diminished as more recent studies were added. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Observational Studies as Topic* | - |
dc.subject.MESH | Randomized Controlled Trials as Topic* | - |
dc.subject.MESH | Resuscitation/methods* | - |
dc.subject.MESH | Shock, Septic/mortality | - |
dc.subject.MESH | Shock, Septic/therapy* | - |
dc.title | Protocol-Based Resuscitation for Septic Shock: A Meta-Analysis of Randomized Trials and Observational Studies | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Woo Kyung Lee | - |
dc.contributor.googleauthor | Ha Yeon Kim | - |
dc.contributor.googleauthor | Jinae Lee | - |
dc.contributor.googleauthor | Shin Ok Koh | - |
dc.contributor.googleauthor | Jeong Min Kim | - |
dc.contributor.googleauthor | Sungwon Na | - |
dc.identifier.doi | 10.3349/ymj.2016.57.5.1260 | - |
dc.contributor.localId | A04550 | - |
dc.contributor.localId | A01232 | - |
dc.contributor.localId | A02990 | - |
dc.contributor.localId | A04641 | - |
dc.contributor.localId | A00884 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 27401660 | - |
dc.subject.keyword | Sepsis | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | septic shock | - |
dc.subject.keyword | shock | - |
dc.contributor.alternativeName | Kim, Jeongmin | - |
dc.contributor.alternativeName | Kim, Ha Yan | - |
dc.contributor.alternativeName | Na, Sung Won | - |
dc.contributor.alternativeName | Lee, Woo Kyung | - |
dc.contributor.alternativeName | Lee, Jinae | - |
dc.contributor.affiliatedAuthor | Kim, Ha Yan | - |
dc.contributor.affiliatedAuthor | Na, Sung Won | - |
dc.contributor.affiliatedAuthor | Lee, Woo Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Jinae | - |
dc.contributor.affiliatedAuthor | Kim, Jeongmin | - |
dc.citation.volume | 57 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 270 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(5) : 1-270, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48656 | - |
dc.type.rims | ART | - |
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