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IMRT vs. 2D-radiotherapy or 3D-conformal radiotherapy of nasopharyngeal carcinoma : Survival outcome in a Korean multi-institutional retrospective study (KROG 11-06)

 Sung Ho Moon  ;  Kwan Ho Cho  ;  Chang-Geol Lee  ;  Ki Chang Keum  ;  Yeon-Sil Kim  ;  Hong-Gyun Wu  ;  Jin Ho Kim  ;  Yong Chan Ahn  ;  Dongryul Oh  ;  Jong Hoon Lee 
 Strahlentherapie und Onkologie, Vol.192(6) : 377-385, 2016 
Journal Title
 Strahlentherapie und Onkologie 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Carcinoma ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/mortality* ; Nasopharyngeal Neoplasms/radiotherapy* ; Neoplasm Recurrence, Local/mortality* ; Neoplasm Recurrence, Local/prevention & control* ; Prevalence ; Radiotherapy, Conformal/mortality* ; Radiotherapy, Conformal/statistics & numerical data ; Radiotherapy, Intensity-Modulated/mortality* ; Radiotherapy, Intensity-Modulated/statistics & numerical data ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Survival Rate ; Treatment Outcome
Intensity-modulated radiotherapy ; Nasopharyngeal neoplasms ; Radiotherapy
OBJECTIVE: We compared treatment outcomes of two-dimensional radiotherapy (2D-RT), three-dimensional conformal radiotherapy (3D-CRT), and intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS: In total, 1237 patients with cT1-4N0-3M0 NPC were retrospectively analyzed. Of these, 350, 390, and 497 were treated with 2D-RT, 3D-CRT, and IMRT, respectively. RESULTS: 3D-CRT and IMRT showed better 5-year overall survival (OS) rates (73.6 and 76.7?%, respectively) than did 2D-RT (5-year OS of 59.7?%, all p?<?0.001). In T3-4 subgroup, IMRT was associated with a significantly better 5-year OS than was 2D-RT (70.7 vs. 50.4?%, respectively; p?≤?0.001) and 3D-CRT (70.7 vs. 57.8?%, respectively; p?=?0.011); however, the difference between the 2D-RT and 3D-CRT groups did not reach statistical significance (p?=?0.063). In multivariate analyses of all patients, IMRT was a predictive factor for OS when compared with 2D-RT or 3D-CRT, as was 3D-CRT when compared with 2D-RT. CONCLUSION: Our study showed that 3D-CRT and IMRT were associated with a better local progression-free survival and OS than was 2D-RT in NPC. IMRT was significantly superior in terms of OS for advanced primary tumors (T3-4).
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
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