Cited 2 times in
Performance of the BacT Alert 3D System Versus Solid Media for Recovery and Drug Susceptibility Testing of Mycobacterium tuberculosis in a Tertiary Hospital in Korea
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2017-10-26T07:42:55Z | - |
dc.date.available | 2017-10-26T07:42:55Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152415 | - |
dc.description.abstract | Background : Tuberculosis (TB) is a major health problem, and accurate and rapid diagnosis of multidrug-resistant (MDR) and extended drug-resistant (XDR) TB is important for appropriate treatment. In this study, performances of solid and liquid culture methods were compared with respect to MDR- and XDR-TB isolate recovery and drug susceptibility testing. Methods : Sputum specimens from 304 patients were stained with Ziehl-Neelsen method. Mycobacterium tuberculosis (Mtb) isolates were tested for recovery on L?wenstein-Jensen (LJ) medium and the BacT Alert 3D system. For drug susceptibility testing of Mtb, isolates were evaluated on M-KIT plates and the BacT Alert 3D system. Results : The recovery rates were 94.9% (206/217) and 98.2% (213/217) for LJ medium and the BacT Alert 3D system, respectively (kappa coefficient, 0.884). The rate of drug resistance was 13.4% for at least one or more drugs, 6.0% for MDR-TB and 2.3% for XDR-TB. M-KIT plate and BacT 3D Alert 3D system were comparable in drug susceptibility testing for isoniazid (97.7%; kappa coefficient, 0.905) and rifampin (98.6%; kappa coefficient, 0.907). Antibiotic resistance was observed using M-KIT plates for 24 of the total 29 Mtb isolates (82.8%). Conclusion : The liquid culture system showed greater reduction in the culture period, as compared with LJ medium; however, drug susceptibility testing using M-KIT plates was advantageous for simultaneous testing against multiple drug targets. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한결핵 및 호흡기학회 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Performance of the BacT Alert 3D System Versus Solid Media for Recovery and Drug Susceptibility Testing of Mycobacterium tuberculosis in a Tertiary Hospital in Korea | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Seoung-Cheol Kim | - |
dc.contributor.googleauthor | Bo-Young Jeon | - |
dc.contributor.googleauthor | Jin-Sook Kim | - |
dc.contributor.googleauthor | In Hwan Choi | - |
dc.contributor.googleauthor | Jiro Kim | - |
dc.contributor.googleauthor | Jeongim Woo | - |
dc.contributor.googleauthor | Soojin Kim | - |
dc.contributor.googleauthor | Hyeong Woo Lee | - |
dc.contributor.googleauthor | Monoldorova Sezim | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.identifier.doi | 10.4046/trd.2016.79.4.282 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02761 | - |
dc.identifier.eissn | 2005-6184 | - |
dc.relation.journalsince | 2004~ | - |
dc.identifier.pmid | 27790280 | - |
dc.relation.journalbefore | ~2004 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환) | - |
dc.subject.keyword | Drug Susceptibility | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | Tertiary Care Center | - |
dc.subject.keyword | Tuberculosis | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.citation.volume | 79 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 282 | - |
dc.citation.endPage | 288 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.79(4) : 282-288, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48622 | - |
dc.type.rims | ART | - |
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