Cited 6 times in
Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2017-10-26T07:38:10Z | - |
dc.date.available | 2017-10-26T07:38:10Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152308 | - |
dc.description.abstract | PURPOSE: The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1 colon cancer cells. MATERIALS AND METHODS: The effects of troglitazone, PDT, and troglitazone in combination with PDT on cell viability and apoptosis were assessed in DLD-1 cells. Cell viability and proliferation were evaluated using the tetrazolium-based MTT assay, and apoptosis was evaluated via cell staining with propidium iodide (PI) and annexin V-FITC. The levels of pro-caspase-3 were measured via Western blot analyses. RESULTS: Treatment of troglitazone and PDT induced the growth retardation and cell death of DLD-1 cells in a dose-dependent manner, respectively. The combination treatment significantly suppressed cell growth and increased the apoptotic response of DLD-1 and resulted in apoptosis rather than necrosis, as shown by PI/annexin V staining and degradation of procaspase-3. CONCLUSION: These results document the anti-proliferative and apoptotic activities of PDT in combination with the PPARγ ligand troglitazone and provide a strong rationale for testing the therapeutic potential of combination treatment in colon cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Caspase 3 | - |
dc.subject.MESH | Cell Cycle/drug effects | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects* | - |
dc.subject.MESH | Cell Survival/drug effects* | - |
dc.subject.MESH | Chromans/pharmacology* | - |
dc.subject.MESH | Colonic Neoplasms/metabolism | - |
dc.subject.MESH | Colonic Neoplasms/pathology | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | PPAR gamma/metabolism | - |
dc.subject.MESH | PPAR gamma/pharmacology* | - |
dc.subject.MESH | Photochemotherapy* | - |
dc.subject.MESH | Tetrazolium Salts | - |
dc.subject.MESH | Thiazoles | - |
dc.subject.MESH | Thiazolidinediones/pharmacology* | - |
dc.subject.MESH | Thiazolidinediones/therapeutic use | - |
dc.title | Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Hyunju Park | - |
dc.contributor.googleauthor | Si-Hwan Ko | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Youn-Hee Choi | - |
dc.identifier.doi | 10.3349/ymj.2016.57.6.1494 | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 27593880 | - |
dc.subject.keyword | PDT | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | troglitazone | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | Park, Jeon Han | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1494 | - |
dc.citation.endPage | 1499 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(6) : 1494-1499, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48043 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.