124 264

Cited 9 times in

Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

 Boyoung Park  ;  Sohee Park  ;  Hai-Rim Shin  ;  Aesun Shin  ;  Yohwan Yeo  ;  Ji-Yeob Choi  ;  Kyu-Won Jung  ;  Byoung-Gie Kim  ;  Yong-Man Kim  ;  Dong-Young Noh  ;  Sei-Hyun Ahn  ;  Jae Weon Kim  ;  Sokbom Kang  ;  Jae Hoon Kim  ;  Tae Jin Kim  ;  Daehee Kang  ;  Keun-Young Yoo  ;  Sue K. Park 
 BMC CANCER, Vol.16 : 5, 2016 
Journal Title
Issue Date
Adult ; Breast Neoplasms/epidemiology* ; Breast Neoplasms/physiopathology ; Contraceptives, Oral/adverse effects ; Female ; Humans ; Maternal Age ; Ovarian Neoplasms/epidemiology* ; Ovarian Neoplasms/physiopathology ; Pregnancy ; Reproduction/physiology* ; Reproductive History* ; Republic of Korea ; Risk Factors
Population attributable fraction ; Breast cancer ; Ovarian cancer ; Modifiable factors ; Reproductive factors
BACKGROUND: Breast and ovarian cancers are predominant female cancers with increasing prevalence. The purpose of this study was to estimate the population attributable risks (PARs) of breast and ovarian cancer occurrence based on the relative risks (RRs) of modifiable reproductive factors and population-specific exposure prevalence. METHODS: The PAR was calculated by using the 1990 standardized prevalence rates, the 2010 national cancer incidence with a 20 year lag period, the meta-analyzed RRs from studies conducted in the Korean population for breast cancer, and the meta-analyzed RRs from a Korean epithelial ovarian cancer study and a prior meta-analysis, and ovarian cancer cohort results up to 2012. For oral contraceptive and hormone replacement therapy use, we did not consider lag period. RESULTS: The summary PARs for modifiable reproductive factors were 16.7% (95% CI 15.8-17.6) for breast cancer (2404 cases) and 81.9% (95% CI 55.0-100.0) for ovarian cancer (1579 cases). The modifiable reproductive factors included pregnancy/age at first birth (8.0%), total period of breastfeeding (3.1%), oral contraceptive use (5.3%), and hormone replacement therapy use (0.3%) for breast cancer and included breastfeeding experience (2.9%), pregnancy (1.2%), tubal ligation (24.5%), and oral contraceptive use (53.3%) for ovarian cancer. CONCLUSIONS: Despite inherent uncertainties in the risk factors for breast and ovarian cancers, we suggest that appropriate long-term control of modifiable reproductive factors could reduce breast and ovarian cancer incidences and their related burdens by 16.7% and 81.9%, respectively.
Files in This Item:
T201604201.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Park, So Hee(박소희) ORCID logo https://orcid.org/0000-0001-8513-5163
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.