Cited 20 times in
Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering
DC Field | Value | Language |
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dc.contributor.author | 성학준 | - |
dc.date.accessioned | 2017-10-26T07:36:21Z | - |
dc.date.available | 2017-10-26T07:36:21Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152262 | - |
dc.description.abstract | In this study, we developed poly(?-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. β-cyclodextrin (βCD) was grafted to hydroxyapatite (HAp) and this βCD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the βCD and adamantane (AD) or between βCD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the β-CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | POLYMERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering | - |
dc.type | Article | - |
dc.publisher.location | Switzerland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Medical Engineering | - |
dc.contributor.googleauthor | Jung Bok Lee | - |
dc.contributor.googleauthor | Ji Eun Kim | - |
dc.contributor.googleauthor | Min Soo Bae | - |
dc.contributor.googleauthor | Su A Park | - |
dc.contributor.googleauthor | Daniel A. Balikov | - |
dc.contributor.googleauthor | Hak-joon Sung | - |
dc.contributor.googleauthor | Hoon Bong Jeon | - |
dc.contributor.googleauthor | Hun Kuk Park | - |
dc.contributor.googleauthor | Soong Ho Um | - |
dc.contributor.googleauthor | Kook Sun Lee | - |
dc.contributor.googleauthor | Il Keun Kwon | - |
dc.identifier.doi | 10.3390/polym8020049 | - |
dc.contributor.localId | A01958 | - |
dc.relation.journalcode | J03041 | - |
dc.identifier.eissn | 2073-4360 | - |
dc.relation.journalsince | 2009 | - |
dc.contributor.alternativeName | Sung, Hak-Joon | - |
dc.contributor.affiliatedAuthor | Sung, Hak-Joon | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 49 | - |
dc.identifier.bibliographicCitation | POLYMERS, Vol.8(2) : 49, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 47998 | - |
dc.type.rims | ART | - |
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