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Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress

Authors
 Hyoung Yoon Chang  ;  Dong In Suh  ;  Song-I. Yang  ;  Mi-Jin Kang  ;  So-Yeon Lee  ;  Eun Lee  ;  In Ae Choi  ;  Kyung-Sook Lee  ;  Yee-Jin Shin  ;  Youn Ho Shin  ;  Yoon Hee Kim  ;  Kyung Won Kim  ;  Kangmo Ahn  ;  Hye-Sung Won  ;  Suk-Joo Choi  ;  Soo-Young Oh  ;  Ja-Young Kwon  ;  Young Han Kim  ;  Hee Jin Park  ;  Kyung-Ju Lee  ;  Jong Kwan Jun  ;  Ho-Sung Yu  ;  Seung-Hwa Lee  ;  Bok Kyoung Jung  ;  Ji-Won Kwon  ;  Yoon Kyung Choi  ;  Namhee Do  ;  Yun Jin Bae  ;  Ho Kim  ;  Woo-Sung Chang  ;  Eun-Jin Kim  ;  Jeom Kyu Lee  ;  Soo-Jong Hong 
Citation
 Journal of Allergy and Clinical Immunology, Vol.138(2) : 468-475, 2016 
Journal Title
 Journal of Allergy and Clinical Immunology 
ISSN
 0091-6749 
Issue Date
2016
MeSH
Adult ; Biomarkers ; Child, Preschool ; Comorbidity ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/etiology* ; Dermatitis, Atopic/metabolism* ; Female ; Humans ; Infant ; Male ; Maternal Exposure*/adverse effects ; Middle Aged ; Odds Ratio ; Oxidative Stress ; Pregnancy ; Prenatal Exposure Delayed Effects* ; Proportional Hazards Models ; Risk Factors ; Stress, Physiological* ; Stress, Psychological* ; Young Adult
Keywords
Anxiety ; atopic dermatitis ; cohort ; depression ; prenatal ; psychological stress ; reactive oxygen species
Abstract
BACKGROUND: Recent evidence suggests that prenatal maternal distress increases the risk of allergic diseases in offspring. However, the effect of prenatal maternal depression and anxiety on atopic dermatitis (AD) risk remains poorly understood. OBJECTIVE: We investigated whether prenatal maternal distress is associated with AD risk in offspring and whether the mechanism is mediated by reactive oxygen species. METHODS: Two general population-based birth cohorts formed the study. One cohort (Cohort for Childhood Origin of Asthma and Allergic Diseases [COCOA]) consisted of 973 mother-baby dyads, and the other (Panel Study on Korean Children [PSKC]) consisted of 1531 mother-baby dyads. The association between prenatal distress and AD was assessed by using Cox proportional hazards and logistic regression models. In COCOA placental 11β-hydroxysteroid dehydrogenase type 2 and glutathione levels and serum IgE levels in 1-year-old children were measured. RESULTS: In COCOA and PSKC AD occurred in 30.6% (lifetime prevalence) and 11.6% (1 year prevalence) of offspring, respectively. Prenatal maternal distress increased the risk of AD in offspring, both in COCOA (hazard ratio for depression, 1.31 [95% CI, 1.02-1.69]; hazard ratio for anxiety, 1.41 [95% CI, 1.06-1.89]) and PSKC (odds ratio for distress, 1.85 [95% CI, 1.06-3.25]). In COCOA both prenatal maternal depression and anxiety scores were positively related to the predicted probability of AD (P < .001 in both). Prenatal distress decreased placental glutathione to glutathione disulfide ratios (P = .037) and, especially in those who later had AD, decreased placental 11β-hydroxysteroid dehydrogenase type 2 levels (P = .010) and increased IgE levels at 1 year of age (P = .005). CONCLUSION: Prenatal maternal depression and anxiety promote risk of AD in offspring. Maternal distress increases the predicted probability of AD. The mechanism might involve chronic stress, abnormal steroid levels, and reactive oxygen species.
Full Text
http://www.sciencedirect.com/science/article/pii/S009167491600261X?via%3Dihub
DOI
10.1016/j.jaci.2016.01.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
권자영(Kwon, Ja Young) ORCID logo https://orcid.org/0000-0003-3009-6325
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김영한(Kim, Young Han) ORCID logo https://orcid.org/0000-0003-0645-6028
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
신의진(Shin, Yee Jin) ORCID logo https://orcid.org/0000-0001-8573-4342
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152214
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