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Interaction between 25-hydroxyvitamin D and variants at 17q12-21 on respiratory infections

 Youn Ho Sheen  ;  Eun Lee  ;  Mi-Jin Kang  ;  Ho-Sung Yu  ;  Kangmo Ahn  ;  Kyung Won Kim  ;  Song-I Yang  ;  Young-Ho Jung  ;  Kyung-Ju Lee  ;  Hyoung Yoon Chang  ;  Hye Lim Shin  ;  Kil Yong Choi  ;  Hyung Young Kim  ;  Ju-Hee Seo  ;  Ji-Won Kwon  ;  Byoung-Ju Kim  ;  Hyo-Bin Kim  ;  So-Yeon Lee  ;  Dong In Suh  ;  Hyeon-Jong Yang  ;  Suk-Joo Choi  ;  Soo-Young Oh  ;  Ja-Young Kwon  ;  Soo Hyun Kim  ;  Hye-Sung Won  ;  Eun-Jin Kim  ;  Jeom Kyu Lee  ;  Soo-Jong Hong 
 Pediatric Pulmonology, Vol.51(9) : 958-967, 2016 
Journal Title
 Pediatric Pulmonology 
Issue Date
Chromosomes, Human, Pair 17/genetics* ; Disease Susceptibility ; Female ; Fetal Blood/metabolism ; Humans ; Infant ; Male ; Odds Ratio ; Polymorphism, Single Nucleotide* ; Prospective Studies ; Respiratory Tract Infections/complications* ; Respiratory Tract Infections/genetics* ; Risk Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/complications*
17q12-21 ; cohort study ; gene-environment interaction ; polymorphism ; prenatal programming ; respiratory tract infections ; vitamin D
OBJECTIVES: 25-hydroxyvitamin D (25[OH]D) deficiency and genetic variants at the 17q12-21 locus are independent risk factors for respiratory tract infections (RTIs). We aimed to investigate whether the effect of 25(OH)D at birth and 1 year of age and the polymorphism at the 17q12-21 locus, or interactions between these two factors, increase susceptibility to RTIs in the first year of life. METHODS: We tested cord-blood (CB) 25(OH)D at birth and 1 year of age and genotypes of a variant at the 17q12-21 locus for associations with RTIs, particularly lower respiratory tract infections (LRTIs), and determined whether there exist interactions between 25(OH)D and 17q12-21 genotypes in a birth cohort of 473 infants. RESULTS: The levels of CB 25(OH)D inversely associate with development of RTIs and LRTIs during the first year of life. There exists an inverse association of 25(OH)D at birth, but not at 1 year, with the risk of acquiring LRTIs in early infancy (adjusted odds ratio [aOR], 2.37; 95% confidence interval [CI]: 1.23-4.60; P?=?0.010 and aOR, 0.50; 95%CI: 0.23-1.12; P?=?0.094). We have also found a significant interaction between CB 25(OH)D and a variant at the 17q12-21 locus with respect to the development of early LRTIs, such that associations between a variant at the 17q12-21 locus and LRTIs are restricted to infants with low CB 25(OH)D concentrations (P for interaction?=?0.013). In addition, when infants with a variant at the 17q12-21 locus had been exposed to chronic 25(OH)D deficiency over the first year, their risk of LRTIs was increased. CONCLUSION: CB 25(OH)D deficiency during fetal life contribute to the development of LRTIs in genetically susceptible infants.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
권자영(Kwon, Ja Young) ORCID logo https://orcid.org/0000-0003-3009-6325
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
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