Cited 11 times in

Changes in bone metabolism in young castrated male rats

Authors
 Seong-Jun Ryu  ;  Dal-Sung Ryu  ;  Jong-Yeol Kim  ;  Jeong-Yoon Park  ;  Kyung-Hyun Kim  ;  Dong-Kyu Chin  ;  Keun-Su Kim  ;  Yong-Eun Cho  ;  Sung-Uk Kuh 
Citation
 YONSEI MEDICAL JOURNAL, Vol.57(6) : 1386-1394, 2016 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2016
MeSH
Alkaline Phosphatase/metabolism ; Animals ; Biomarkers/blood* ; Bone Density* ; Bone Remodeling ; Bone Resorption ; Collagen Type I/metabolism ; Female ; Femur/metabolism* ; Humans ; Lumbar Vertebrae/metabolism ; Male ; Orchiectomy/adverse effects* ; Osteocalcin/metabolism ; Osteogenesis ; Osteoporosis/metabolism ; Peptides ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; X-Ray Microtomography*
Keywords
Osteoporosis ; bone mineral density ; femur ; orchiectomy ; spine
Abstract
PURPOSE: To determine the window of time during which osteoporosis affects the management of spinal surgery and the mechanism of bone metabolism changes in males with osteoporosis by examining changes in bone metabolism in young castrated male rats.

MATERIALS AND METHODS: A total of 30 Sprague-Dawley rats were randomly allocated into two study groups. Group 1 (control) received a sham surgery and Group 2 received bilateral orchiectomy to change bone mineral density (BMD). Serum osteocalcin, alkaline phosphatase (ALP), and collagen type 1 cross-linked C-telopeptide (CTX) were analyzed at postoperative date (POD) 8, 10, and 12 weeks. BMDs were measured using micro computed tomography scans.

RESULTS: Femoral and lumbar BMDs were decreased in the orchiectomy groups. BMDs in the sham and orchiectomy groups showed statistically differences at POD 8, 10, and 12 weeks for the femur (p=0.032, 0.008, 0.008) and lumbar spine (p=0.151, 0.008, 0.008, respectively). Serum osteocalcin, ALP, and CTX decreased gradually; however, N-terminal type 1 procollagen (P1NP) showed a slight increase yet no significant change.

CONCLUSION: In young castrated male rats, a significant decrease in BMD was observed after orchiectomy due to the mixture of two detrimental factors. Young castrated male rats did not reach peak BMD. Increased bone turnover causes bone resorption to exceed bone formation. This study may contribute to the creation of a valuable model for studies of male osteoporosis and the spinal surgery field.
Files in This Item:
T201603728.pdf Download
DOI
10.3349/ymj.2016.57.6.1386
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kuh, Sung Uk(구성욱) ORCID logo https://orcid.org/0000-0003-2566-3209
Kim, Kyung Hyun(김경현)
Kim, Keun Su(김근수) ORCID logo https://orcid.org/0000-0002-3384-5638
Ryu, Dal Sung(류달성)
Park, Jeong Yoon(박정윤) ORCID logo https://orcid.org/0000-0002-3728-7784
Cho, Yong Eun(조용은) ORCID logo https://orcid.org/0000-0001-9815-2720
Chin, Dong Kyu(진동규) ORCID logo https://orcid.org/0000-0002-9835-9294
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152166
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links